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CASE REPORT article

Front. Psychiatry

Sec. Aging Psychiatry

Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1551581

This article is part of the Research Topic Healthy Aging in Action: Addressing the Challenges of Cognitive Decline and Dementia and Contributing to a Better Future for Population Aging View all 7 articles

Case report: Lewy body dementia with unusual psychotic symptoms, atypically late parkinsonism, and patient sensitivity to first generation antipsychotics

Provisionally accepted
  • Riga Stradiņš University, Riga, Latvia

The final, formatted version of the article will be published soon.

    Lewy body dementia is associated with abnormal eosinophilic A-synuclein neural inclusions (Lewy bodies) in the brain. It is a neurodegenerative illness-and the second most common type of dementia after Alzheimer's disease-that causes memory loss and severe problems in carrying out daily activities. In this report, we describe a case of Lewy body dementia that began with early psychotic symptoms with atypical features (transition from hallucinosis (hallucinatory insight) to true visual hallucinations)-without Parkinsonism. The patient exhibited sensitivity to first generation antipsychotic medication, which led to a worsening of her symptoms. Physicians should consider all possible diagnoses when confronted with atypical, early symptoms of visual hallucinosis or true hallucinations and dementia without Parkinsonism. Choosing antipsychotic medicines should be made with care given these patients' possible sensitivity to antipsychotics. The selection of antipsychotics should be consider among first, second and third generation options.

    Keywords: Dementia, Lewi bodies, psychosis, Antipsychotics, Sensitivity

    Received: 25 Dec 2024; Accepted: 20 Mar 2025.

    Copyright: © 2025 Ercika and Taube. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Māris Taube, Riga Stradiņš University, Riga, Latvia

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