Toward Objective Biomarkers in Psychiatric Rehabilitation: Detecting the "Berger Effect" with a sheet-type EEG Device

China Shiroma¹Keita Ueno¹Masaya Ueda¹Takao INOUE¹Masahiro Hata²Shun Takahashi²Keigo Shiraiwa³Junya Orui⁴Fumie Tazaki³Yasuo Naito¹Ryouhei Ishii^1*

• ¹Osaka Metropolitan University, Osaka, Japan
• ²Osaka University, Suita, Ōsaka, Japan
• ³Osaka Kawasaki Rehabilitation University, Kaizuka, Ōsaka, Japan
• ⁴Osaka Health Science University, Osaka, Japan

For individuals undergoing psychiatric rehabilitation, there is an urgent need to establish an objective biomarker of brain activity without invasive or behavioral restrictions. To investigate an objective index for potential psychiatric rehabilitation assessment and intervention strategies in the future, we tried to detect the "Berger effect", the alpha EEG reactivity to eyes opening, and to verify the suitability of a sheet-type electroencephalography (EEG) device, HARU-1. We measured EEG of 20 healthy young to middle-aged subjects using HARU-1 from the forehead area during resting closedeye and open-eye conditions. Fast Fourier transform and time-frequency analysis were then performed on the data from all subjects in the resting closed-eye and resting open-eye conditions. Statistical analysis found that the reference electrode derivation method showed a significant increase in alpha waves and a significant decrease in beta and gamma waves in the three forehead channels of Fp1, Fp2 and AFz during the resting closed eye condition compared to the resting open eye condition. In the bipolar derivation method, all Fp1-AFz, Fp2-Fp1 and AFz-Fp2 showed a significant decrease in the β and γ bands at approximately 13-50 Hz. These results demonstrated that HARU-1 accurately measured the "Berger effect" in the forehead region, suggesting that HARU-1 may be useful in detecting objective biomarkers of brain activity during psychiatric rehabilitation.