AUTHOR=Mai Jiaxi , Zhou Tingwei , Wang Chen , Ye Junrong , Chen Jiao , Wang Wen , Pan Yuanxin , Wei Yanheng , Yuan Lexin , Yang Hang , Wu Shengwei , Guo Jianxiong , Xiao Aixiang TITLE=Evaluating the effectiveness of integrated traditional Chinese and Western treatment based on symptom grading: a study protocol for a multi-center, randomized controlled trial of patients with depressive disorder JOURNAL=Frontiers in Psychiatry VOLUME=16 YEAR=2025 URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1491410 DOI=10.3389/fpsyt.2025.1491410 ISSN=1664-0640