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ORIGINAL RESEARCH article
Front. Psychiatry
Sec. Neuroimaging
Volume 16 - 2025 |
doi: 10.3389/fpsyt.2025.1486835
This article is part of the Research Topic Advances in Brain Functional Network Reconfiguration in Psychosis View all articles
Improved brain functional network in major depressive disorder with suicidal ideation after individual target-transcranial magnetic stimulation treatment: a graph-theory analysis
Provisionally accepted
Yao Zhang
1*
Nan Mu
1*
Shun Qi
2
Chuanzhu Sun
3*
Yang Rao
3*
Xinyi Yang
1*
Jianying Guo
1*
Yunfeng Mu
4*- 1 Xijing Hospital, Air Force Medical University, Xi’an, Shaanxi Province, China
- 2 Xi'an Jiaotong University, Xi'an, China
- 3 Shaanxi Brain Modulation and Scientific Research Center, Xi'an, China
- 4 Shaanxi Provincial Cancer Hospital, Xi'an, China
Major depressive disorder with suicidal ideation (MDD/SI+) is characterized by high prevalence, high recurrence rate, high disability rate and low response rate. There is an urgent need for clarifying the pathogenesis and developing novel treatment methods. Subjects were recruited for the collection of Magnetic Resonance Imaging data and clinical scales. Individual target-transcranial magnetic stimulation (IT-TMS) using Stanford Neuromodulation Therapy over individualized left dorsolateral prefrontal cortex was performed to treat MDD/SI+ with the ethical approval (KY20212218-C-1). GRETNA software was used to analyze brain network characteristics according to graph theory. A total of 32 patients (aged 18-55) and 28 healthy controls (aged 20-51) had been recruited. Patients after IT-TMS treatment had significant reduction in suicidal ideation and depressive symptom. The functional network of all three groups conformed to small-world topology. There was a renormalization in topology structure after IT-TMS treatment. Decreased functional connectivity between right insula and left anterior cingulate gyrus correlated with improvement in Beck Scale for Suicide Ideation scores. The current study highlights that MDD/SI+ patients in this cohort showed abnormal brain network connections compared to healthy controls MDD/SI+ is a disorder characterized by abnormal brain network connections with impaired information integration ability, and that IT-TMS may exert its treatment effects by reducing spontaneous hyper-connectivity in the salience network and insula.
Keywords: Depression, Suicidal Ideation, Transcranial Magnetic Stimulation, Small-world, graph-theory
Received: 27 Aug 2024; Accepted: 03 Jan 2025.
Copyright: © 2025 Zhang, Mu, Qi, Sun, Rao, Yang, Guo and Mu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yao Zhang, Xijing Hospital, Air Force Medical University, Xi’an, Shaanxi Province, China
Nan Mu, Xijing Hospital, Air Force Medical University, Xi’an, Shaanxi Province, China
Chuanzhu Sun, Shaanxi Brain Modulation and Scientific Research Center, Xi'an, China
Yang Rao, Shaanxi Brain Modulation and Scientific Research Center, Xi'an, China
Xinyi Yang, Xijing Hospital, Air Force Medical University, Xi’an, Shaanxi Province, China
Jianying Guo, Xijing Hospital, Air Force Medical University, Xi’an, Shaanxi Province, China
Yunfeng Mu, Shaanxi Provincial Cancer Hospital, Xi'an, China
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