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SYSTEMATIC REVIEW article

Front. Psychiatry
Sec. Schizophrenia
Volume 15 - 2024 | doi: 10.3389/fpsyt.2024.1506353

The role of anti-inflammatory diets and supplementation in metabolic syndrome and symptoms remission in adults with schizophrenia: A systematic review

Provisionally accepted
Elizabeth Suschana Elizabeth Suschana 1*Thea Anderson Thea Anderson 1Catriona Hong Catriona Hong 1Arun Narikatte Arun Narikatte 2Jillian Silverberg Jillian Silverberg 1Man Suresh Sharma Man Suresh Sharma 3
  • 1 School of Medicine, University of Connecticut, Farmington, United States
  • 2 Frank H. Netter MD School of Medicine, Quinnipiac University, North Haven, Connecticut, United States
  • 3 Institute of Living, Hartford Hospital, Hartford, Connecticut, United States

The final, formatted version of the article will be published soon.

    as potential pathways in metabolic syndrome and schizophrenia. Anti-inflammatory diets have potential to treat not only metabolic syndrome but also reduce symptom burden in schizophrenia. The aim of the systematic review is to investigate the role of anti-inflammatory diets and vitamin supplementation in the management of metabolic syndrome as well as symptom remission in people with schizophrenia.The systematic review contained research articles from PubMed, EMBASE, Scopus, PsychINFO, and Cochrane Central Register for Controlled Trials. The primary outcomes were markers of metabolic syndrome and symptoms of psychosis.Results: Our search identified 2124 potential studies, of which 1559 were screened based on title and abstract, leading to 81 full-text articles assessed for eligibility. 17 studies were included and demonstrated mixed findings on the impacts of antiinflammatory diet interventions on metabolic markers and symptom remission in schizophrenia. Prebiotic, probiotic, and fish oil supplementation showed improvements in metabolic markers. Fish oil and vitamin D supplementation demonstrated symptom remission in some trials. Conclusion: It is important to consider that people with schizophrenia may experience common external barriers that hinder adherence to dietary interventions. These findings underscore the need for larger trials with standardized dietary protocols and consistent metabolic and symptom outcome measures to better understand the potential role of anti-inflammatory interventions in this population.

    Keywords: Schizophrenia, Anti-inflammatory diets, Inflammation, Vitamins, Supplements, metabolic syndrome

    Received: 05 Oct 2024; Accepted: 02 Dec 2024.

    Copyright: © 2024 Suschana, Anderson, Hong, Narikatte, Silverberg and Sharma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Elizabeth Suschana, School of Medicine, University of Connecticut, Farmington, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.