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ORIGINAL RESEARCH article

Front. Psychiatry
Sec. Mood Disorders
Volume 15 - 2024 | doi: 10.3389/fpsyt.2024.1497658
This article is part of the Research Topic Understanding Vulnerability to Major Depressive Disorder View all 10 articles

The prevalence and clinical correlation factors of cognitive impairment in patients with major depressive disorder hospitalized during the acute phase

Provisionally accepted
huiyuan Zhao huiyuan Zhao jinhong chen jinhong chen *
  • Second People’s Hospital of Hunan Province, Yuhua, Hunan Province, China

The final, formatted version of the article will be published soon.

    Objective: This study aimed to investigate the prevalence of cognitive impairment among patients with major depressive disorder (MDD) hospitalized during the acute phase and to analyze the in-depth association between this cognitive impairment and clinical correlation factors. Methods: In this cross-sectional study, we recruited 126 patients aged between 18 and 65 years who were diagnosed with MDD. All these patients were inpatients from the Department of Psychiatry at the Second People's Hospital of Hunan Province. We employed a series of assessment tools, including the Pittsburgh Sleep Quality Index (PSQI), the 16-item Dysfunctional Beliefs and Attitudes about Sleep Scale (DBAS-16), the Pre-sleep Arousal Scale (PSAS), the Morningness-Eveningness Questionnaire (MEQ), the Hamilton Anxiety Rating Scale (HAMA), and the 17-item Hamilton Depression Rating Scale (HAMD-17). The patients were divided into a cognitive impairment group and a non-cognitive impairment group based on their score on the Montreal Cognitive Assessment Scale (MoCA). Through Spearman correlation analysis, we explored the correlation between the total MoCA score and the score of each factor. Additionally, we utilized binary logistic regression analysis to investigate the relationship between cognitive impairment and clinically relevant factors in MDD patients hospitalized during the acute phase, and plotted ROC curves to evaluate their clinical efficacy.In this study, we found that the prevalence of cognitive impairment among MDD patients hospitalized during the acute phase was as high as 63.49%. Through statistical analysis, we observed significant differences between the cognitive impairment group and the non-cognitive impairment group in terms of age, place of residence, education level, and the HAMD-17 score. In the Spearman correlation analysis, we noted the following trends: visuospatial and executive abilities were negatively correlated with the HAMD-17 score (P < 0.05); naming ability was positively correlated with the PSAS score but negatively correlated with the MEQ score (P < 0.05); memory was also negatively correlated with the MEQ score (P < 0.05); Through binary logistic regression analysis, we further revealed the relationship between cognitive impairment and factors such as rural living area (OR = 2.7, 95% CI = 1.083-6.731, P < 0.05),

    Keywords: cognitive impairment, major dpression disorder, acute phase, clinical correlation factors cognitive impairment, Major Depression Disorder, clinical correlation factors

    Received: 17 Sep 2024; Accepted: 21 Oct 2024.

    Copyright: © 2024 Zhao and chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: jinhong chen, Second People’s Hospital of Hunan Province, Yuhua, 410007, Hunan Province, China

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