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CASE REPORT article

Front. Psychiatry
Sec. Psychopathology
Volume 15 - 2024 | doi: 10.3389/fpsyt.2024.1485502

Case Report: Recurrence of Psychosis after the Surgical Resection and Radiation of a Temporal Lobe Astrocytoma

Provisionally accepted
David Perekopskiy David Perekopskiy 1Shervin Zoghi Shervin Zoghi 1Jenna Dobrick Jenna Dobrick 1*Orwa Aboud Orwa Aboud 2,3,4James Alan Bourgeois James Alan Bourgeois 1*
  • 1 Department of Psychiatry and Behavioral Sciences, School of Medicine, University of California, Davis, Sacramento, California, United States
  • 2 Department of Neurological Surgery, School of Medicine, University of California, Davis, Davis, California, United States
  • 3 Department of Neurology, School of Medicine, University of California, Davis, Sacramento, California, United States
  • 4 Comprehensive Cancer Center, School of Medicine, University of California, Davis, Sacramento, California, United States

The final, formatted version of the article will be published soon.

    It is estimated that the incidence of first episode psychotic disorder is about 33 people out of 100,000 each year (1). Beyond primary psychotic illness (e.g., schizophrenia, schizophreniform disorder), some of these patients will develop psychotic disorder due to a complex interplay of genetics, anatomical variations, traumatic brain injury (TBI), environment, substance use, and/or other causes. A small subset of patients will develop psychotic disorder due to a structural anatomic lesion, such as a CNS tumor. Here we present a 35-year-old male with worsening auditory hallucinations after surgical resection and radiation of a right temporal lobe astrocytoma in the setting of co-morbid methamphetamine usage. This case report helps illustrate how a neuroimaging work-up is important for the first incidence of psychotic disorder and how a tumor can produce a psychotic disorder that persists after oncologic treatment. This paper adds to the literature on the presentation and treatment of post-resection tumor-induced psychotic disorder.

    Keywords: psychosis, Neuroimaging, Risperidone, Amphetamine, tumor, Astrocytoma, Secondary psychotic disorders

    Received: 23 Aug 2024; Accepted: 04 Dec 2024.

    Copyright: © 2024 Perekopskiy, Zoghi, Dobrick, Aboud and Bourgeois. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jenna Dobrick, Department of Psychiatry and Behavioral Sciences, School of Medicine, University of California, Davis, Sacramento, 95817, California, United States
    James Alan Bourgeois, Department of Psychiatry and Behavioral Sciences, School of Medicine, University of California, Davis, Sacramento, 95817, California, United States

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