The final, formatted version of the article will be published soon.
ORIGINAL RESEARCH article
Front. Psychiatry
Sec. Neuroimaging
Volume 15 - 2024 |
doi: 10.3389/fpsyt.2024.1474313
Divergent pattern of functional connectivity within the dorsal attention network differentiates schizophrenia and bipolar disorder patients
Provisionally accepted- 1 Department of Adult Psychiatry, Chair of Psychiatry, Jagiellonian University, Medical College, Krakow, Kraków, Lesser Poland, Poland
- 2 Department of Adult, Child and Adolescent Psychiatry, University Hospital in Cracow, Kraków, Lesser Poland, Poland
- 3 J. Dietl Specialist Hospital, Kraków, Lesser Poland, Poland
- 4 Department of Cognitive Neuroscience and Neuroergonomics, Institute of Applied Psychology, Jagiellonian University, Kraków, Lesser Poland, Poland
- 5 Doctoral School in the Social Sciences, Jagiellonian University, Krakow, Poland
- 6 Jagiellonian University Medical College, Chair of Radiology, Kraków, Poland, Kraków, Poland
- 7 Faculty of Psychology, SWPS University of Social Sciences and Humanities, Katowice, Poland, Katowice, Poland
- 8 Department of Affective Disorders, Chair of Psychiatry, Jagiellonian University, Medical College, Krakow, Kraków, Poland
Introduction: Schizophrenia (SZ) and bipolar disorder (BD) share common clinical features, symptoms and neurocognitive deficits, what results in common misdiagnosis. Recently it has been suggested that alterations within brain networks associated with perceptual organization yield potential to distinguish SZ and BD individuals. The aim of our study was to evaluate whether functional connectivity (FC) of the dorsal attention network (DAN) may differentiate both conditions.Methods: The study involved 90 participants: 30 remitted SZ patients, 30 euthymic BD patients and 30 healthy controls (HC). Resting state functional magnetic resonance imaging was used to compare the groups in terms of the FC within the core nodes of the DAN, involving frontal eye fields (FEF) and intraparietal sulcus (IPS) Results: BD patients presented weaker inter-hemispheric FC between right and left FEF than HC. While SZ did not differ from HC in terms of inter-FEF connectivity, they have presented increased inter-and intra-hemispheric FC between FEF and IPS. When compared with BD, SZ patients showed increased FC between right FEF and other nodes of the network (bilateral IPS and left FEF) Conclusion: We have shown that altered resting state FC within DAN differentiates BD, SZ and HC groups. Divergent pattern of FC within DAN consisting of hypoconnectivity in BD and hyperconnectivity in SZ, might yield a candidate biomarker for differential diagnosis between both conditions. More highly powered studies are needed to confirm these possibilities.
Keywords: parietal cortex, frontal eye fields, resting state, Functional Networks, Schizophrenia, bipolar disorder Brady, R. O., Tandon
Received: 01 Aug 2024; Accepted: 26 Aug 2024.
Copyright: © 2024 Chrobak, Bielak, Nowaczek, Żyrkowska, Sobczak, Fafrowicz, Bryll, Marek, Dudek and Siwek. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Marcin Siwek, Department of Affective Disorders, Chair of Psychiatry, Jagiellonian University, Medical College, Krakow, Kraków, Poland
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.