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MINI REVIEW article

Front. Psychiatry
Sec. Molecular Psychiatry
Volume 15 - 2024 | doi: 10.3389/fpsyt.2024.1470642
This article is part of the Research Topic Non-Neuronal Cells in Neurodegenerative Diseases and Psychiatric Disorders View all articles

The use of induced pluripotent stem cells (iPSCs) as a platform for the study of depression

Provisionally accepted
Javier Villafranco Javier Villafranco 1,2,3Gabriela Martínez-Ramírez Gabriela Martínez-Ramírez 2,3Roxana Magaña-Maldonado Roxana Magaña-Maldonado 1Anna Paola González-Ruvalcaba Anna Paola González-Ruvalcaba 1Adolfo Lopez Adolfo Lopez 4Ivan Velasco Ivan Velasco 1,5Enrique Becerril-Villanueva Enrique Becerril-Villanueva 3Lenin Pavón Lenin Pavón 3Enrique Estudillo Enrique Estudillo 1*Gilberto Pérez-Sánchez Gilberto Pérez-Sánchez 3*
  • 1 Laboratorio de Reprogramación Celular, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México, Mexico
  • 2 Facultad de Estudios Superiores Iztacala. UNAM., Ciudad de México, Mexico
  • 3 Laboratorio de Psicoinmunología, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñíz, Ciudad de México, Mexico
  • 4 División de Investigación, Hospital Juárez de México, Ciudad de México, Mexico
  • 5 Instituto de Fisiología Celular-Neurociencias, Universidad Nacional Autónoma de México., Ciudad de México, Mexico

The final, formatted version of the article will be published soon.

    The neurobiological mechanisms underlying major depressive disorder (MDD) remain largely unexplored due to the limited availability of study models in humans. Induced pluripotent stem cells (iPSCs) have overcome multiple limitations of retrospective clinical studies, contributing to a more detailed understanding of the molecular pathways that presumably contribute to the manifestation of depression. Despite the significant progress made by these study models, there are still more formidable challenges that will eventually be addressed by these platforms, as further studies may eventually emerge. This review will examine the most recent advances in the comprehension of depression by using human neurons and non-neuronal cells derived from induced pluripotent stem cells of patients with depression. This study highlights the importance of using these platforms to increase our knowledge of depression and address this psychiatric disorder more efficiently.

    Keywords: iPSCs, Stem Cells, Depression, Neurons, glia, Astrocytes

    Received: 25 Jul 2024; Accepted: 17 Sep 2024.

    Copyright: © 2024 Villafranco, Martínez-Ramírez, Magaña-Maldonado, Paola González-Ruvalcaba, Lopez, Velasco, Becerril-Villanueva, Pavón, Estudillo and Pérez-Sánchez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Enrique Estudillo, Laboratorio de Reprogramación Celular, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México, Mexico
    Gilberto Pérez-Sánchez, Laboratorio de Psicoinmunología, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñíz, Ciudad de México, Mexico

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.