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ORIGINAL RESEARCH article

Front. Psychiatry
Sec. Mood Disorders
Volume 15 - 2024 | doi: 10.3389/fpsyt.2024.1467142

Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio(NHHR) with depressive symptoms: recent findings from NHANES 2005-2018

Provisionally accepted
Chunyu Yan Chunyu Yan 1yabin zhou yabin zhou 2*changxing wang changxing wang 1*He Wang He Wang 2*Jiamei Fu Jiamei Fu 2*
  • 1 Heilongjiang University of Chinese Medicine, Harbin, China
  • 2 First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China

The final, formatted version of the article will be published soon.

    The ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) index is a relatively new composite lipid index,the relationship between NHHR and depression is unclear from the current study.The primary aim of our study was to examine the association between the prevalence of depression and NHHR in a US population.provided the data for our investigation from 2005 to 2018. and primarily included participants who contained complete data on NHHR and depression in U.S. adults (age ≥20 years). Associations between NHHR and depression were assessed using multifactorial logistic regression analysis,subgroup analysis, and smoothed curve fitting.Results:In our study, 29,561 subjects in total showed a mean NHHR index of 3.12± 1.58,A noteworthy positive correlation was observed between NHHR and depression in multifactorial logistic regression analysis.Subgroup analyses and tests of interaction showed that gender, age, ethnicity, PIR, smoking, alcohol consumption, coronary heart disease, diabetes mellitus, hypertension, and stroke did not influence the NHHR and the association between depression (P for interaction > 0.05), whereas two stratification factors, BMI and sleep disturbance, may be potential factors in the association between NHHR and depression (P for interaction < 0.05).According to our present study, if the level of NHHR rises in American adults, their likelihood of developing depression also increases.

    Keywords: NNHR, Depression, NHANES, US adults, Cross-sectional study

    Received: 19 Jul 2024; Accepted: 14 Oct 2024.

    Copyright: © 2024 Yan, zhou, wang, Wang and Fu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    yabin zhou, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
    changxing wang, Heilongjiang University of Chinese Medicine, Harbin, China
    He Wang, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
    Jiamei Fu, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China

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