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REVIEW article

Front. Psychiatry
Sec. Mood Disorders
Volume 15 - 2024 | doi: 10.3389/fpsyt.2024.1463848

Efficacy of Bifidobacterium-Related Preparations on Depression: The First Meta-Analysis

Provisionally accepted
Ruihan Huang Ruihan Huang Yongsheng Liu Yongsheng Liu *
  • Qilu Medical University, Zibo City, Shandong, China

The final, formatted version of the article will be published soon.

    Currently, depression-induced suicide has emerged as the primary contributor to the worldwide burden of disability(Monroe and Harkness 2022). However, the prevailing drug treatment not only suffers from delayed effectiveness and limited efficacy, but also there are withdrawal symptoms and rebound phenomenon (Henssler et al. 2019;Dilsaver and Greden 1984;Horowitz et al. 2023).Consequently, there is an imperative to investigate safer and more efficient treatments to ameliorate the clinical manifestations of depression. At present, there is increased evidence that probiotics can improve the symptoms of depression, but the existing studies use many and mixed types of probiotics (Chudzik et al. 2021;Liu, Walsh, and Sheehan 2019), and it is impossible to determine the specific efficacy of bifidobacteria in the treatment of depression. This review will systematically review the effects of bifidobacteria on the treatment effect of depression, Meta-analysis showed that Bifidobacterium-related preparations effectively improved depressive symptoms in patients with depression.This study represents the initial meta-analysis conducted on the use of bifidobacteria-related agents for treating depression. The objective was to determine the effect of bifidobacteria-related preparations on improving depressive symptoms.We found that Bifidobacterium and its related agents can effectively reduce depression scale scores in patients with depression, suggesting the need for further research into this potential strategy for the prevention and treatment of depression.

    Keywords: psychobiotics, Bifidobacterium, Depression, treatment outcome, Meta-analysis

    Received: 12 Jul 2024; Accepted: 05 Sep 2024.

    Copyright: © 2024 Huang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yongsheng Liu, Qilu Medical University, Zibo City, 255213, Shandong, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.