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ORIGINAL RESEARCH article

Front. Psychiatry
Sec. Psychological Therapy and Psychosomatics
Volume 15 - 2024 | doi: 10.3389/fpsyt.2024.1456890

Remediating cognitive inflexibility in obsessive compulsive disorder and anorexia nervosa neither moderates nor mediates treatment effects: an exploratory study

Provisionally accepted
Boris van Passel Boris van Passel 1,2*Unna Danner Unna Danner 3,4Alexandra Dingemans Alexandra Dingemans 5Theo Broekman Theo Broekman 6Lot Sternheim Lot Sternheim 3,4Eni Becker Eni Becker 2Annemarie Van Elburg Annemarie Van Elburg 3,4Eric van Furth Eric van Furth 5,7Gert-Jan Hendriks Gert-Jan Hendriks 1,2,8Danielle Cath Danielle Cath 10,9
  • 1 Overwaal Centre of Expertise for Anxiety Disorders, OCD and PTSD, Institution for Integrated Mental Health Care, Pro Persona, Nijmegen, Netherlands
  • 2 Behavioural Science Institute, Radboud University, Nijmegen, Netherlands
  • 3 Altrecht Eating Disorders Rintveld, Zeist, Netherlands
  • 4 Department of Clinical Psychology, Faculty of Social and Behavioural Sciences, Utrecht University, Utrecht, Netherlands
  • 5 Rivierduinen Eating Disorders Ursula, Leiden, Netherlands
  • 6 Buro Beta, Nijmegen, Netherlands
  • 7 Department of Psychiatry, Leiden University Medical Center (LUMC), Leiden, South Holland, Netherlands
  • 8 Department of Psychiatry, Radboud University Medical Center, Nijmegen, Netherlands
  • 9 GGZ Drenthe, Assen, Netherlands
  • 10 Department of Psychiatry, University Medical Center Groningen, Groningen, Netherlands

The final, formatted version of the article will be published soon.

    This study received a ZonMW grant, project number 837001004The data reported in this manuscript were collected as part of a larger data collection. The dataanalyses reported in this manuscript have not been published elsewhere. Findings from the data collection have been reported in separate articles. Manuscript 1 (van Passel et al., 2016) presents the study protocol; this paper has been written before data collection. In Manuscript 2 (van Passel et al., 2020) we compared the effectiveness of CRT and SAT as add-ons to TAU with main outcome measure the Y-BOCS and the EDE-Q for OCD and AN pathology. Manuscript 3 (Sternheim et al., 2022) presents the differences in measures of cognitive flexibility and a measure of central coherence between three groups: patients with OCD, patients with AN, and HCs. The current article differs from prior publications in its focus on cognitive flexibility as a moderator and/or a mediator of treatment effect. The trial design was approved by the Medical Ethics Committee of the University Medical Centre Utrecht approved the study (METc no. NL43751.041.13 v0.3). The trial was registered in The Netherlands Trial Register (www.trialregister.nl, identifier: 3865).

    Keywords: Obsessive Compulsive Disorder, Anorexia Nervosa, cognitive flexibility, cognitive remediation therapy, moderation analysis

    Received: 29 Jun 2024; Accepted: 09 Dec 2024.

    Copyright: © 2024 Passel, Danner, Dingemans, Broekman, Sternheim, Becker, Van Elburg, Furth, Hendriks and Cath. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Boris van Passel, Overwaal Centre of Expertise for Anxiety Disorders, OCD and PTSD, Institution for Integrated Mental Health Care, Pro Persona, Nijmegen, Netherlands

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.