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REVIEW article
Front. Psychiatry
Sec. Autism
Volume 15 - 2024 |
doi: 10.3389/fpsyt.2024.1451242
This article is part of the Research Topic Improving Outcomes in Autism Spectrum Disorders for Adults View all articles
Targeting the Circadian Modulation: Novel Therapeutic Approaches in the Management of ASD
Provisionally accepted- 1 University of Texas Health Science Center at Houston, Houston, United States
- 2 Hunan University of Chinese Medicine, Changsha, Anhui Province, China
Circadian dysfunction is prevalent in neurodevelopmental disorders, particularly in autism spectrum disorder (ASD). A plethora of empirical studies demonstrate a strong correlation between ASD and circadian disruption, suggesting that modulation of circadian rhythms and the clocks could yield satisfactory advancements. Research indicates that circadian dysfunction associated with abnormal neurodevelopmental phenotypes in ASD individuals, potentially contribute to synapse plasticity disruption. Therefore, targeting circadian rhythms may emerge as a key therapeutic approach. In this study, we did a brief review of the mammalian circadian clock, and the correlation between the circadian mechanism and the pathology of ASD at multiple levels. In addition, we highlight that circadian is the target or modulator to participate in the therapeutic approaches in the management of ASD, such as phototherapy, melatonin, modulating circadian components, natural compounds, and chronotherapies. A deep understanding of the circadian clock's regulatory role in the neurodevelopmental phenotypes in ASD may inspire novel strategies for improving ASD treatment.
Keywords: Circadian clock, Neurodevelopmental disorders, Autism Spectrum Disorder, therapeutic approaches, Chronotherapies
Received: 18 Jun 2024; Accepted: 09 Sep 2024.
Copyright: © 2024 Zhang, Chen, Li, Tang, Li and Feng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yinan Chen, Hunan University of Chinese Medicine, Changsha, 410208, Anhui Province, China
Wu Li, Hunan University of Chinese Medicine, Changsha, 410208, Anhui Province, China
Liya Tang, Hunan University of Chinese Medicine, Changsha, 410208, Anhui Province, China
Jiangshan Li, Hunan University of Chinese Medicine, Changsha, 410208, Anhui Province, China
Xiang Feng, Hunan University of Chinese Medicine, Changsha, 410208, Anhui Province, China
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