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ORIGINAL RESEARCH article

Front. Psychiatry
Sec. Psychopathology
Volume 15 - 2024 | doi: 10.3389/fpsyt.2024.1442954
This article is part of the Research Topic Immunometabolic Alterations Linked to Affective Disorders and Other Mental Illnesses View all articles

Retrospective Evaluation of Novel Serum Inflammatory Biomarkers in First-Episode Psychiatric Disorders: Diagnostic Potential and Immune Dysregulation

Provisionally accepted
Min Qiu Min Qiu 1Chenkai Zhang Chenkai Zhang 2*Haiqing Zhang Haiqing Zhang 1*Hao Chen Hao Chen 1*Yingjia Lei Yingjia Lei 1*Ping Li Ping Li 1*Shaochuan Zhang Shaochuan Zhang 1*
  • 1 Yunnan Psychiatric Hospital, Kunming, China
  • 2 Yunnan Fuwai Cardiovascular Hospital, Kunming, Yunnan Province, China

The final, formatted version of the article will be published soon.

    Background: This study assessed the diagnostic capabilities of eight inflammatory biomarkers in first-episode schizophrenia (SCZ), bipolar disorder (BD), and depression (D), examining their differential expression across these psychiatric disorders. The markers studied include neutrophils/lymphocyte ratio (NLR), aggregate index of systemic inflammation (AISI), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), lymphocytes/highdensity lipoprotein (HDL) ratio (LHR), monocytes/HDL ratio (MHR), neutrophils/HDL ratio (NHR), and platelets/HDL ratio (PHR). Methods: We conducted a retrospective observational study involving 335 individuals with SCZ, 68 with BD, 202 with D, and 282 healthy controls (C) to evaluate hematologic parameters from untreated patients and controls. Results: Significant differences in biomarker levels were found between patient groups and controls. Logistic regression analysis indicated that NHR and MHR (p < 0.001), as well as LHR and NLR (p < 0.01), were predictive factors for SCZ. MHR was a predictive factor for BD (p < 0.05). NHR (p < 0.01) and MHR (p < 0.001) were predictive factors for distinguishing between D and C. The area under the curve (AUC) value of the NHR + MHR + NLR composite index model for the SCZ group was 0.846 (p < 0.001). In the BD group, the AUC value for the MHR was 0.816 (p < 0.001). The D group's combined AUC value of NHR + MHR was 0.824 (p < 0.001). Conclusion: This study highlights the diagnostic value of inflammatory biomarkers in distinguishing SCZ, BD, and D based on their differential expression.

    Keywords: Systemic inflammatory index, systemic inflammation response index, Lipid Metabolism, biomarker, Psychiatric disorder

    Received: 03 Jun 2024; Accepted: 26 Nov 2024.

    Copyright: © 2024 Qiu, Zhang, Zhang, Chen, Lei, Li and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Chenkai Zhang, Yunnan Fuwai Cardiovascular Hospital, Kunming, Yunnan Province, China
    Haiqing Zhang, Yunnan Psychiatric Hospital, Kunming, China
    Hao Chen, Yunnan Psychiatric Hospital, Kunming, China
    Yingjia Lei, Yunnan Psychiatric Hospital, Kunming, China
    Ping Li, Yunnan Psychiatric Hospital, Kunming, China
    Shaochuan Zhang, Yunnan Psychiatric Hospital, Kunming, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.