Issifou YAYA ^1* Yvenie Amboise ¹ Guillaume Roucoux ¹ Lisa Yombo-Kokule ¹ Fabienne Marcellin ² Claudine Duvivier ³ Karine Lacombe ⁴ James Griffith ⁵ Marie Préau ⁶ Antoine Cheret ⁷ Martin Duracinsky ⁸

• ¹ 1- Patient-Reported Outcomes Research (PROQOL), Health Economics Clinical Trial Unit (URC-ECO), Hotel-Dieu Hospital, AP- HP, Paris, France. 2- ECEVE, UMR-S 1123, Paris Cité University, Inserm, Paris, France., Assistance Publique Hopitaux De Paris, Paris, France
• ² Aix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l’Information Médicale, ISSPAM, Aix-Marseille Université, Marseille, Provence-Alpes-Côte d'Azur, France
• ³ Necker Hospital, AP-HP, Infectious Diseases Department, Necker-Pasteur Infectiology Center, Paris, France; Inserm U1016, CNRS UMR 8104, Université Paris Descartes, Institut Cochin, Université Paris Cité, Paris, Île-de-France, France
• ⁴ 5 Hôpital Saint-Antoine, Assistance Publique Des Hôpitaux de Paris, Service Des Maladies Infectieuses Et Tropicales, Cedex 12, 75571 Paris, France. 6 INSERM, Pierre Louis Institute of Epidemiology and Public Health (IPLESP), Sorbonne University, 75646, Assistance Publique Hopitaux De Paris, Paris, France
• ⁵ Feinberg School of Medicine Department of Medical Social Sciences Northwestern University Chicago Illinois USA, University of Illinois Chicago, Chicago, Illinois, United States
• ⁶ Inserm Unit 1296 « Radiations : Defense, Health, Environment », Lumière University Lyon 2, Lyon, Rhône-Alpes, France
• ⁷ 9 Plateforme de Diagnostic et de Thérapeutique Pluridisciplinaire, CHU Guadeloupe, France 10 INSERM, U1016, CNRS, UMR8104, Institut Cochin, Paris, France., Centre Hospitalier Universitaire Guadeloupe, Pointe-à-Pitre, France
• ⁸ 1- Patient-Reported Outcomes Research (PROQOL), Health Economics Clinical Trial Unit (URC-ECO), Hotel-Dieu Hospital, AP- HP, Paris, France. 2- ECEVE, UMR-S 1123, Paris Cité University, Inserm, Paris, France. 11- Internal Medicine Unit, Le Kremlin Bicêtre Hospital, Bicêtre, France., Assistance Publique Hopitaux De Paris, Paris, France

The COVID-19 pandemic has severely affected vulnerable populations, especially individuals living with HIV/AIDS (PLWHA). The convergence of HIV/AIDS and COVID-19 presents unique challenges, exacerbating existing health concerns and magnifying the strain on individuals already grappling with compromised immune systems. This study aimed to investigate the mental well-being repercussions faced by PLWHA co-infected with SARS-CoV-2 in France.COVIDHIV is a French multicentre cohort of PLWHA co-infected with SARS-CoV-2, which collected sociodemographic, clinical, and mental health data. Anxiety and depression symptoms and post-traumatic stress disorder (PTSD) were assessed by the Hospital Anxiety and Depression Scale (HADS) and the PTSD Checklist (PCL-S), respectively. Multivariable logistic regression was performed to identify factors associated with mental health outcomes at inclusion in the cohort.Results: Of the 397 participants included, 64.7% were male. The mean age was 51.6 (±11.8) years. The prevalence of mental health outcomes was 33.5% ([95%CI: 28.5-39.0%]) for anxiety, 21.0% ([16.8-25.9%]) for depression, and 12.2% ([8.9-16.5%]) for PTSD. In multivariable regression adjusted for sex, COVID-19 wave and duration between COVID-19 confirmation and enrolment, age (adjusted odds-ratio (aOR): 0.97 [0.95-0.99]), being professionally active (0.43 [0.25-0.75]), and the number of self-reported symptoms (1.17 [1.11-1.24]) were associated with anxiety. Being professionally active (0.34 [0.18-0.65]), living in a couple (0.52 [0.20-0.98]), number of self-reported symptoms (1.15 [1.08-1.22]), and hospitalization for ) were associated with depression. The number of self-reported symptoms (1.27 [1.16-1.41]), psychiatric disorders (4. 04 [1.48-11.11]), and perceived vulnerability to ) were associated with PTSD.The mental health is a challenging issue among the participants and needs to be closely monitored among people already affected by a chronic disease such as HIV. The findings underscore the urgent need for targeted support and interventions tailored to address the mental health needs of PLWHA facing the dual burden of HIV/AIDS and COVID-19.