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ORIGINAL RESEARCH article
Front. Psychiatry
Sec. Schizophrenia
Volume 15 - 2024 |
doi: 10.3389/fpsyt.2024.1436142
Influencing factors of different metabolic status in hospitalized patients with schizophrenia
Provisionally accepted- 1 Fourth People's Hospital of Wuhu, Wuhu, Anhui Province, China
- 2 Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, China
The aim of this study was to explore the risk factors for different metabolic status in patients with schizophrenia. Methods: A total of 968 hospitalized patients with schizophrenia were recruited. Fasting blood glucose (GLU) and lipid profile, including total cholesterol (TC), lowdensity lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) were measured. Schizophrenia patients were divided into four groups: normal metabolism and weight (NMNW), abnormal metabolism and normal weight (AMNM), normal metabolism and overweight/obesity (NMO), and abnormal metabolism and overweight/obesity (AMO). Results: Our results showed NMNW, AMNW, NMO and AMO accounted for 25.3%, 12.7%, 25.4% and 36.6%, respectively. There were significant differences in age, disease during, BMI, waist circumference, chronic disease, SBP, DBP, GLU, TG, TC, HDL-C and LDL-C among these four groups (all P < 0.05). With NMNW group as the reference, the disordered multiple classification regression analysis showed that chronic disease was a significant risk factor for AMNW (OR = 5.271, 95% CI = 3.165 to 8.780, P < 0.001) and AMO (OR = 3.245, 95% CI = 2.004 to 5.254, P < 0.001), age was an important protective factor for NMO (OR = 0.968, 95% CI = 0.943 to 0.994, P = 0.015) and AMO (OR = 0.973, 95% CI = 0.948 to 0.999, P < 0.042), waist circumference was a significant risk factor for NMO (OR = 1.218, 95% CI = 1.180 to 1.257, P < 0.001) and AMO (OR = 1.252, 95% CI = 1.212 to 1.291, P < 0.001), and college education was an obvious protective factor for AMO (OR = 0.343, 95% CI = 0.123 to 0.953, P < 0.040) among patients with schizophrenia.The findings of our study underscored the importance of factors such as age, education level, chronic disease and waist circumference when exploring the influencing factors and biological mechanisms of obesity-related metabolic problems in schizophrenia patients.
Keywords: Schizophrenia, Obesity, Metabolism, Risk factors, Glucose, Lipid
Received: 21 May 2024; Accepted: 02 Jul 2024.
Copyright: © 2024 Ding, Zhang, Zhu, Cai, Fang, Zhou, Zhang and Fang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiangrong Zhang, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, China
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