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ORIGINAL RESEARCH article

Front. Psychiatry
Sec. Mood Disorders
Volume 15 - 2024 | doi: 10.3389/fpsyt.2024.1432538

The Impact of Sleep Disturbances on Treatment Efficacy and Prognosis in Patients with Depressive and Anxiety Disorders

Provisionally accepted
Qingyu Zhang Qingyu Zhang 1Maoqing Tong Maoqing Tong 1Yunxin Ji Yunxin Ji 1*Yanbin Hou Yanbin Hou 1Zhongze Lou Zhongze Lou 1Danjuan Wu Danjuan Wu 1Yuwei Mi Yuwei Mi 1*Pingping Miao Pingping Miao 1*Jiaxin Tian Jiaxin Tian 2Zhenzhen Zhu Zhenzhen Zhu 3*Liemin Ruan Liemin Ruan 1*
  • 1 Department of Psychosomatic Medicine, Ningbo First Hospital, Ningbo, Zhejiang Province, China
  • 2 Ningbo University, Ningbo, Zhejiang Province, China
  • 3 Department of Psychiatry, Ningbo Kangning Hospital, Ningbo, Zhejiang Province, China

The final, formatted version of the article will be published soon.

    Little was known about the relationship between sleep disturbances and depressive and anxiety disorders, as well as the efficacy of treatment regimens. During 2021 to 2023, a total of 417 participants were screened by Hamilton Depression Rating Scale (HAMD-17) and Hamilton Anxiety Rating Scale (HAMA-14) for psychological status, and Pittsburgh sleep quality index (PSQI) assessment. 409 participants were finally enrolled, of which 188 (45.97%) were suffered from sleep disorders. All participants were received polysomnography (PSG) followed by six-week pharmacological treatment of escitalopram and zopiclone, and finally assessed by HAMD-17 and HAMA-14 for treatment efficacy. PSG monitoring indicated that participants with depression experienced prolonged rapid eye movement sleep latency (REMSL) and increased wakefulness after sleep onset (WASO) (P=0.030 and P=0.002, respectively). Those with anxiety disorders demonstrated a significantly higher percentage of non-rapid eye movement sleep (NREM%) and reduced WASO (P=0.013 and P=0.001, respectively). After six-weeks pharmacological treatment, participants with or without sleep disorders exhibited with similar efficacy outcomes of depression and anxiety disorders (P>0.05). However, every point of PSQI increment at baseline would decrease 0.78 and 0.85 times of probability of effective pharmacological treatment of depression and anxiety disorders. Moreover, participants with both effective outcomes of depression and anxiety disorders were found siginificant shorter sleep onset latency (SOL) (P<0.001). The insights gained underscore the necessity of considering sleep disturbances in enhancing the overall effectiveness of pharmacological treatments for depression and anxiety disorders.

    Keywords: Zhu zhenzhen, Ruan liemin Sleep disturbances1, Depressive and Anxiety Disorders2, Polysomnography3, Antidepressant Therapy4, Treatment Efficacy5

    Received: 16 May 2024; Accepted: 18 Sep 2024.

    Copyright: © 2024 Zhang, Tong, Ji, Hou, Lou, Wu, Mi, Miao, Tian, Zhu and Ruan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yunxin Ji, Department of Psychosomatic Medicine, Ningbo First Hospital, Ningbo, Zhejiang Province, China
    Yuwei Mi, Department of Psychosomatic Medicine, Ningbo First Hospital, Ningbo, Zhejiang Province, China
    Pingping Miao, Department of Psychosomatic Medicine, Ningbo First Hospital, Ningbo, Zhejiang Province, China
    Zhenzhen Zhu, Department of Psychiatry, Ningbo Kangning Hospital, Ningbo, Zhejiang Province, China
    Liemin Ruan, Department of Psychosomatic Medicine, Ningbo First Hospital, Ningbo, Zhejiang Province, China

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