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ORIGINAL RESEARCH article

Front. Psychiatry
Sec. Mood Disorders
Volume 15 - 2024 | doi: 10.3389/fpsyt.2024.1425681
This article is part of the Research Topic Understanding Vulnerability to Major Depressive Disorder View all 5 articles

Preventive and therapeutic effect of vitamin D on depression-like behavior in a mouse adolescent depression model and its association with BDNF protein expression

Provisionally accepted
Xueping Yang Xueping Yang 1*Junxiao Miao Junxiao Miao 1Yinglin Huang Yinglin Huang 2LIli Li LIli Li 3Gengsen Zhuang Gengsen Zhuang 4
  • 1 The People's Hospital of Liaoning Province, Shenyang, China
  • 2 Sheng Jing Hospital Affiliated, China Medical University, Shenyang, Liaoning Province, China
  • 3 The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China
  • 4 The Medical University of Dalian, Dalian, Liaoning Province, China

The final, formatted version of the article will be published soon.

    Adolescence is an important period of psychological development, a stage of continuous growth and dynamic change. Physiological, psychosocial, and cognitive changes make adolescents susceptible to psychological disorders. Depression is a psychological disorder with a high incidence and is the leading cause of disability worldwide. A meta-analysis showed that the global point prevalence of depression was 34% between 2001 and 2020 based on self-reported depressive symptoms.The point prevalence of major depressive disorder (MDD) and dysthymia was 8% and 4%, respectively. Furthermore, depressive symptoms in adolescents increased from 24% between 2001 and 2010 to 37% between 2011 and 2020. The Middle East, Africa, and Asia have the highest prevalence of elevated depressive symptoms. [1] Since depression typically begins in adolescence, juvenile cases are more likely to be first cases, while adult cases may be relapses from earlier juvenile cases. Symptomatic characteristics differ between adults and adolescents. Autonomic dysregulation symptoms (insomnia, fatigue, and changes in appetite and weight) are more common in adolescents with MDD than in adults. Further, anhedonia/loss of interest and concentration problems are more common in adults with MDD.

    Keywords: Depression, Vitamin D, BDNF, depression model, Mouse

    Received: 30 Apr 2024; Accepted: 05 Jul 2024.

    Copyright: © 2024 Yang, Miao, Huang, Li and Zhuang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xueping Yang, The People's Hospital of Liaoning Province, Shenyang, China

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