Skip to main content

REVIEW article

Front. Psychiatry
Sec. Molecular Psychiatry
Volume 15 - 2024 | doi: 10.3389/fpsyt.2024.1419574

Possible roles of neuropeptide/transmitter and autoantibody modulation in emotional problems and aggression

Provisionally accepted
Henning Værøy Henning Værøy 1*Regina Skar-Fröding Regina Skar-Fröding 1*Elin Hareton Elin Hareton 1*Sergueï O. Fetissov Sergueï O. Fetissov 2*
  • 1 Akershus University Hospital, Lørenskog, Norway
  • 2 Université de Rouen, Mont-Saint-Aignan, Upper Normandy, France

The final, formatted version of the article will be published soon.

    The theoretical foundations of understanding psychiatric disorders are undergoing changes. Explaining behaviour and neuroendocrine cell communication leaning towards immunology represents a different approach compared to previous models for understanding complex central nervous system processes. One such approach is the study of immunoglobulins or autoantibodies, and their effect on peptide hormones in the neuro-endocrine system. In the present review, we provide an overview of the literature on neuropeptide/transmitter and autoantibody modulation in psychiatric disorders featuring emotional problems and aggression, including associated illness behavior. Finally, we discuss the role of psycho-immunology as a growing field in the understanding of psychiatric disorders, and that modulation and regulation by IgG autoAbs represent a relatively new subcategory in psychoimmunology, where studies are currently being conducted.

    Keywords: neuropeptides1, autoantibodies2, emotional problems3, aggression4, psycho-immunology5

    Received: 18 Apr 2024; Accepted: 30 Aug 2024.

    Copyright: © 2024 Værøy, Skar-Fröding, Hareton and Fetissov. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Henning Værøy, Akershus University Hospital, Lørenskog, Norway
    Regina Skar-Fröding, Akershus University Hospital, Lørenskog, Norway
    Elin Hareton, Akershus University Hospital, Lørenskog, Norway
    Sergueï O. Fetissov, Université de Rouen, Mont-Saint-Aignan, 76821, Upper Normandy, France

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.