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REVIEW article
Front. Psychiatry
Sec. Molecular Psychiatry
Volume 15 - 2024 |
doi: 10.3389/fpsyt.2024.1419574
Possible roles of neuropeptide/transmitter and autoantibody modulation in emotional problems and aggression
Provisionally accepted- 1 Akershus University Hospital, Lørenskog, Norway
- 2 Université de Rouen, Mont-Saint-Aignan, Upper Normandy, France
The theoretical foundations of understanding psychiatric disorders are undergoing changes. Explaining behaviour and neuroendocrine cell communication leaning towards immunology represents a different approach compared to previous models for understanding complex central nervous system processes. One such approach is the study of immunoglobulins or autoantibodies, and their effect on peptide hormones in the neuro-endocrine system. In the present review, we provide an overview of the literature on neuropeptide/transmitter and autoantibody modulation in psychiatric disorders featuring emotional problems and aggression, including associated illness behavior. Finally, we discuss the role of psycho-immunology as a growing field in the understanding of psychiatric disorders, and that modulation and regulation by IgG autoAbs represent a relatively new subcategory in psychoimmunology, where studies are currently being conducted.
Keywords: neuropeptides1, autoantibodies2, emotional problems3, aggression4, psycho-immunology5
Received: 18 Apr 2024; Accepted: 30 Aug 2024.
Copyright: © 2024 Værøy, Skar-Fröding, Hareton and Fetissov. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Henning Værøy, Akershus University Hospital, Lørenskog, Norway
Regina Skar-Fröding, Akershus University Hospital, Lørenskog, Norway
Elin Hareton, Akershus University Hospital, Lørenskog, Norway
Sergueï O. Fetissov, Université de Rouen, Mont-Saint-Aignan, 76821, Upper Normandy, France
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