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ORIGINAL RESEARCH article

Front. Psychiatry
Sec. Adolescent and Young Adult Psychiatry
Volume 15 - 2024 | doi: 10.3389/fpsyt.2024.1413608
This article is part of the Research Topic Youth Mental Health, Particularly in Asian Populations View all 29 articles

Association of the neutrophil-to-platelet ratio with response to electroconvulsive therapy in adolescents with major depressive disorder

Provisionally accepted
Dandan Geng Dandan Geng 1Wenxin Wang Wenxin Wang 2*Ning Du Ning Du 3*Lisa C. NIWENAHISEMO Lisa C. NIWENAHISEMO 1Heyan Xu Heyan Xu 1*Yuna Wang Yuna Wang 1Li Kuang Li Kuang 1*
  • 1 Department of Psychiatry, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
  • 2 First Clinical Medical College, Chongqing Medical University, Chongqing, Chongqing, China
  • 3 Center for Mental Health, University-Town Hospital of Chongqing Medical University, Chongqing, China

The final, formatted version of the article will be published soon.

    Background: Major depressive disorder (MDD) is one of the most serious mental disorders affecting adolescents worldwide. Electroconvulsive therapy (ECT) is widely acknowledged as a first-line treatment for severe depression, but the clinical response varies. Neutrophils and platelets are both related to the progression of MDD. The aim of this study was to investigate the correlation between the neutrophil-to-platelet ratio (NPR) during the acute phase and the effectiveness of ECT treatment.Methods: A total of 138 adolescent MDD patients who received ECT were included in the study. Neutrophil and platelet levels were obtained upon admission. At the same time, treatment response was the primary outcome measure, defined as a reduction of ≥ 50% in the HAMD-17 score from baseline to treatment endpoint, and the secondary outcome measure was remission of depression, defined as a HAMD-17 score ≤ 7.Results: After receiving ECT, 103(74.6%) of all patients responded to treatment and 72(52.2%) achieved remission. Non-responders/non-remitters to ECT tended to have higher levels of NPR at baseline compared to ECT responders/remitters [Non-responder: 3.4 (2.5-4.8) vs 2.7 (2.2-3.5), P = 0.002; Non-remitter: 0.014 (0.011-0.017) vs 0.011 (0.008-0.015), P = 0.03]. In multiple logistic regression, high 3116 删除[K]: NPR (≥ 0.014) remained independently associated with ECT non-response/non-remission after adjusting for confounding factors [Non-responder: OR = 4.911, 95% CI (2.052 -11.754), P < 0.001; Non-remitter: OR = 2.704, 95% CI (1.262 -5.796), P = 0.011]. Conclusion: High NPR correlates with poor ECT efficacy in adolescents with MDD, particularly among female and overweight patients.

    Keywords: Major Depressive Disorder, Electroconvulsive Therapy, adolescents, neutrophil-to-platelet ratio, response

    Received: 07 Apr 2024; Accepted: 06 Nov 2024.

    Copyright: © 2024 Geng, Wang, Du, NIWENAHISEMO, Xu, Wang and Kuang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Wenxin Wang, First Clinical Medical College, Chongqing Medical University, Chongqing, Chongqing, China
    Ning Du, Center for Mental Health, University-Town Hospital of Chongqing Medical University, Chongqing, 401331, China
    Heyan Xu, Department of Psychiatry, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
    Li Kuang, Department of Psychiatry, First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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