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ORIGINAL RESEARCH article
Front. Psychiatry
Sec. Aging Psychiatry
Volume 15 - 2024 |
doi: 10.3389/fpsyt.2024.1404229
This article is part of the Research Topic Mental, Sensory, Physical and Life Style Parameters Related to Cognitive Decline in Aging View all 5 articles
Depressive symptom mediates the association between the number of chronic diseases and cognitive impairment: A multi-center cross-sectional study based on community older adults
Provisionally accepted
Li-Chong Lai
Dong-Mei Huang
*
Jie Peng
*
Xiao-Ying Cao
*
Xiao-Ling Feng
*
Pin-Yue Tao
*
Xiao Pan
*
Qi-Ni Pan
*
Deng-Jing Fan
*
Shu-Yu Lu
*
Cai-Li Li
*
Yan-Fei Pan
*
Peng-Xin Dong
*
Yi-Dan Chai
*
Ping Huang
*
Hai-Chen Wu
*
Hui-Qiao Huang
*- Second Affiliated Hospital of Guangxi Medical University, Nanning, China
The purpose of this study was to understand the relationship between the multiple chronic conditions (MCC), mental health and cognitive function of older adults in the community, and to propose a hypothesis that depressive symptom mediate the number of chronic diseases and cognitive impairment in older adults.Method: Participants aged 65 years and older from 35 communities in 14 cities in Guangxi, China were recruited. The residents' depressive symptom (PHQ-9) and cognitive status (AD-8) were evaluated, Chi-square test was used to explore the effects of different socio-demographic characteristics on depressive symptom and cognitive impairment. Pearson correlation analysis and the process model 4 were used to explore the relationship between the number of chronic diseases, depressive symptom and cognitive impairment.Result: A total of 11,582 older adults were included in our analysis. The rate of MCC reaching 26.53%. Hypertension combined with diabetes accounts for the highest proportion of two chronic diseases (13.2%). Among the combination of three chronic diseases, the highest incidence of coexisting hypertension combined with cervical/lumbar spondylosis, and rheumatoid arthritis (7.1%). In this study, depression symptoms accounted for 12.9% of older adults aged 65 and above, and cognitive impairment accounted for 27.4%. Female, older age, reside in urban areas, lower educational levels, no spouse, live alone, and MCC were risk factors for depressive symptom and cognitive impairment in older adults (P<0.05). depressive symptom had a mediating effect in the number of chronic diseases and cognitive impairment, and the mediating effect (1.109) accounted for 44.13% of the total effect (0.247).The mental health of the older adult needs to be taken seriously, and improving depressive symptom can reduce the occurrence of cognitive impairment in older patients with MCC to a certain extent.
Keywords: No. 166 Daxue East Road, Xixiangtang District, Nanning City, Guangxi, China, 530005 Multiple chronic conditions (MCC), Depressive symptom, cognitive impairment, older adults, Mediating effect
Received: 20 Mar 2024; Accepted: 27 Jun 2024.
Copyright: © 2024 Lai, Huang, Peng, Cao, Feng, Tao, Pan, Pan, Fan, Lu, Li, Pan, Dong, Chai, Huang, Wu and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Dong-Mei Huang, Second Affiliated Hospital of Guangxi Medical University, Nanning, China
Jie Peng, Second Affiliated Hospital of Guangxi Medical University, Nanning, China
Xiao-Ying Cao, Second Affiliated Hospital of Guangxi Medical University, Nanning, China
Xiao-Ling Feng, Second Affiliated Hospital of Guangxi Medical University, Nanning, China
Pin-Yue Tao, Second Affiliated Hospital of Guangxi Medical University, Nanning, China
Xiao Pan, Second Affiliated Hospital of Guangxi Medical University, Nanning, China
Qi-Ni Pan, Second Affiliated Hospital of Guangxi Medical University, Nanning, China
Deng-Jing Fan, Second Affiliated Hospital of Guangxi Medical University, Nanning, China
Shu-Yu Lu, Second Affiliated Hospital of Guangxi Medical University, Nanning, China
Cai-Li Li, Second Affiliated Hospital of Guangxi Medical University, Nanning, China
Yan-Fei Pan, Second Affiliated Hospital of Guangxi Medical University, Nanning, China
Peng-Xin Dong, Second Affiliated Hospital of Guangxi Medical University, Nanning, China
Yi-Dan Chai, Second Affiliated Hospital of Guangxi Medical University, Nanning, China
Ping Huang, Second Affiliated Hospital of Guangxi Medical University, Nanning, China
Hai-Chen Wu, Second Affiliated Hospital of Guangxi Medical University, Nanning, China
Hui-Qiao Huang, Second Affiliated Hospital of Guangxi Medical University, Nanning, China
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