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ORIGINAL RESEARCH article

Front. Psychiatry
Sec. Psychological Therapy and Psychosomatics
Volume 15 - 2024 | doi: 10.3389/fpsyt.2024.1397375
This article is part of the Research Topic Technological Advances in Psychiatric Treatments: A Focused Exploration of Human-Computer Interaction (HCI) and Human Factors in Digital Therapeutics View all articles

The Cerebral Metabolic Mechanism of Group Computer Magnanimous Therapy Based on Magnetic Resonance Spectroscopy: Effects on Improving Magnanimous-enterprising Levels of Lung Cancer Patients

Provisionally accepted
QIANYU LIU QIANYU LIU 1Qihui Ma Qihui Ma 2Sun Qingfeng Sun Qingfeng 1Xuewei Huang Xuewei Huang 3*
  • 1 Guangxi Chest Hospital, Liuzhou, China
  • 2 Huizhou Central People's Hospital, Huizhou, Guangdong Province, China
  • 3 Guangdong Pharmaceutical University, Guangzhou, Guangdong Province, China

The final, formatted version of the article will be published soon.

    Introduction: This study aims to evaluate the effects of Group Computer Magnanimous Therapy (GCMT) on magnanimous-enterprising levels and brain metabolic changes in patients with advanced lung cancer.Methods: In this multicentre, randomised controlled trial, 47 participants diagnosed with advanced-stage (III or IV) lung cancer were randomly assigned to either the GCMT group (GCMTG, n=31) or the control group (CTRLG, n=16). The GCMTG received routine oncotherapy and care along with eight sessions of GCMT over two weeks, while the CTRLG received only oncotherapy and routine care. Psychological and brain metabolic changes were assessed using the Enterprising and Magnanimous Questionnaire (EMQ) and proton magnetic resonance spectroscopy ( 1 H-MRS).Results: After two weeks, the GCMTG showed significant improvements in the EMQ "total score" and "enterprising" dimensions compared to baseline (p < 0.05), while the CTRLG showed no significant changes. Significant increases in NAA/Cr levels were observed in the right amygdala, and significant decreases in mI/Cr levels were observed in the right cingulate gyrus in the GCMTG. Pearson correlation analysis indicated that changes in Cho/Cr levels in the left amygdala and Glx/Cr levels in the left hippocampus were significantly correlated with improvements in the enterprising dimension.Conclusions: GCMT significantly enhanced enterprising attitudes and induced beneficial changes in brain metabolites among patients with advanced lung cancer.Further research with larger sample sizes is warranted to confirm these results and explore the long-term effects of GCMT.

    Keywords: Group computer magnanimous therapy, magnanimous-enterprising level, brain metabolism, lung cancer, psychosomatic effects Trial registration: Chinese Clinical Trial Registry, ChiCTR2100053015

    Received: 07 Mar 2024; Accepted: 18 Nov 2024.

    Copyright: © 2024 LIU, Ma, Qingfeng and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xuewei Huang, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.