AUTHOR=Qian Zirong , Yang Yunbo , Domschke Katharina , Gerlach Alexander L. , Hamm Alfons , Richter Jan , Herrmann Martin J. , Deckert Jürgen , Arolt Volker , Zwanzger Peter , Lotze Martin , Pfleiderer Bettina , Wittchen Hans-Ulrich , Lang Thomas , Ströhle Andreas , Konrad Carsten , Rief Winfried , Suslow Thomas , Jansen Andreas , Kircher Tilo , Straube Benjamin TITLE=Elevated accuracy in recognition of subliminal happy facial expressions in patients with panic disorder after psychotherapy JOURNAL=Frontiers in Psychiatry VOLUME=15 YEAR=2024 URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2024.1375751 DOI=10.3389/fpsyt.2024.1375751 ISSN=1664-0640 ABSTRACT=Background

Individuals with anxiety disorders (ADs) often display hypervigilance to threat information, although this response may be less pronounced following psychotherapy. This study aims to investigate the unconscious recognition performance of facial expressions in patients with panic disorder (PD) post-treatment, shedding light on alterations in their emotional processing biases.

Methods

Patients with PD (n=34) after (exposure-based) cognitive behavior therapy and healthy controls (n=43) performed a subliminal affective recognition task. Emotional facial expressions (fearful, happy, or mirrored) were displayed for 33 ms and backwardly masked by a neutral face. Participants completed a forced choice task to discriminate the briefly presented facial stimulus and an uncovered condition where only the neutral mask was shown. We conducted a secondary analysis to compare groups based on their four possible response types under the four stimulus conditions and examined the correlation of the false alarm rate for fear responses to non-fearful (happy, mirrored, and uncovered) stimuli with clinical anxiety symptoms.

Results

The patient group showed a unique selection pattern in response to happy expressions, with significantly more correct “happy” responses compared to controls. Additionally, lower severity of anxiety symptoms after psychotherapy was associated with a decreased false fear response rate with non-threat presentations.

Conclusion

These data suggest that patients with PD exhibited a “happy-face recognition advantage” after psychotherapy. Less symptoms after treatment were related to a reduced fear bias. Thus, a differential facial emotion detection task could be a suitable tool to monitor response patterns and biases in individuals with ADs in the context of psychotherapy.