AUTHOR=Zhang Ni , Li Jin , Dong Zaiquan , Hu Yongbo , Zhong Zhihui , Gong Qiyong , Kuang Weihong 

TITLE=The digestion and dietary carbohydrate pathway contains 100% gene mutations enrichment among 117 patients with major depressive disorder

JOURNAL=Frontiers in Psychiatry

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2024.1362612

DOI=10.3389/fpsyt.2024.1362612

ISSN=1664-0640

ABSTRACT=<sec><title>Introduction</title><p>Major depressive disorder (MDD) is partially inheritable while its mechanism is still uncertain.</p></sec><sec><title>Methods</title><p>This cross-sectional study focused on gene pathways as a whole rather than polymorphisms of single genes. Deep sequencing and gene enrichment analysis based on pathways in Reactome database were obtained to reveal gene mutations.</p></sec><sec><title>Results</title><p>A total of 117 patients with MDD and 78 healthy controls were enrolled. The Digestion and Dietary Carbohydrate pathway (Carbohydrate pathway) was determined to contain 100% mutations in patients with MDD and 0 mutation in matched healthy controls.</p></sec><sec><title>Discussion</title><p>Findings revealed in the current study enable a better understanding of gene pathways mutations status in MDD patients, indicating a possible genetic mechanism of MDD development and a potential diagnostic or therapeutic target.</p></sec>