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SYSTEMATIC REVIEW article

Front. Psychiatry
Sec. Molecular Psychiatry
Volume 15 - 2024 | doi: 10.3389/fpsyt.2024.1338481

Causal effects between personality and psychiatric traits and lung cancer: A bidirectional two-sample Mendelian randomization and bibliometric study

Provisionally accepted
Siyuan Chen Siyuan Chen 1Zhijuan Du Zhijuan Du 1*Yuhui Qin Yuhui Qin 1Yanan Li Yanan Li 2*Yu Pan Yu Pan 3*Qiao Yu Qiao Yu 4Juan Chen Juan Chen 5*Zhengyang Hou Zhengyang Hou 6*Shuai Jin Shuai Jin 1*Haitao Tao Haitao Tao 1*Heying Yu Heying Yu 2*Jiapei Qin Jiapei Qin 1*Mingzhen Zhu Mingzhen Zhu 7*Yi Hu Yi Hu 1*Zhefeng Liu Zhefeng Liu 1*
  • 1 Department of Medical Oncology, Senior Department of Oncology, The Fifth Medical Center of PLA General Hospital, Beijing, China
  • 2 Department of Medical Oncology, The Third Medical Center of PLA General Hospital, Beijing, China
  • 3 Department of Medical Psychology, Fifth Medical Center of the PLA General Hospital, Beijing, China
  • 4 Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical College, Beijing, China
  • 5 School of Nursing and Public Health, Yangzhou University, Beijing, China
  • 6 Department of Social Management and Social Policy, School of Social Development and Public Policy, Fudan University, Shanghai, Shanghai Municipality, China
  • 7 Department of Thoracic Surgery, Affiliated Hospital of Jining Medical University, Jining, China

The final, formatted version of the article will be published soon.

    Introduction: The causality between personality and psychiatric traits and lung cancer (LC) remains unclear. Therefore, we aimed to elucidate the causality between these traits and LC. Methods: Bidirectional two-sample Mendelian randomization (MR) and bibliometric approaches were conducted to estimate the causality between personality (neuroticism, extraversion, agreeableness, conscientiousness, and openness) and psychiatric (schizophrenia, attention-deficit/hyperactivity disorder [ADHD], major depressive disorder, autism spectrum disorder, bipolar disorder, insomnia, and anxiety) traits and LC and its subtypes (lung squamous cell carcinoma, lung adenocarcinoma, and small cell LC). Summary data of these traits were extracted from large datasets (17,375–462,341 participants). Inverse variance weighting was used as the primary MR analysis, with supplementary models, including MR-Egger and weighted medians. Sensitivity analyses were conducted to detect pleiotropy. Bibliometric data were retrieved from the Web of Science Core Collection, Scopus, and PubMed. The main mapping techniques adopted were co-word, collaboration, and citation analyses. Results: Schizophrenia was associated with an increased risk of LC (odds ratio [OR] = 1.077, 95% confidence interval [CI] = 1.030–1.126, P = 0.001). Moreover, LC increased the risk of ADHD (OR = 1.221, 95% CI = 1.096–1.362, P < 0.001). No significant bidirectional associations were observed between other mental traits and LC and its subtypes. Causality, psychiatry, and psychiatric comorbidity are emerging keywords. Research dynamics and landscapes were revealed. Conclusion: This study suggests that schizophrenia is a risk factor for LC and that LC is a risk factor for ADHD. Furthermore, causality, psychiatry, and psychiatric comorbidity have become emerging research trends in related fields.

    Keywords: psychiatric, Personality, lung cancer, Mendelian randomization, Bibliometric

    Received: 15 Nov 2023; Accepted: 08 Jul 2024.

    Copyright: © 2024 Chen, Du, Qin, Li, Pan, Yu, Chen, Hou, Jin, Tao, Yu, Qin, Zhu, Hu and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zhijuan Du, Department of Medical Oncology, Senior Department of Oncology, The Fifth Medical Center of PLA General Hospital, Beijing, China
    Yanan Li, Department of Medical Oncology, The Third Medical Center of PLA General Hospital, Beijing, China
    Yu Pan, Department of Medical Psychology, Fifth Medical Center of the PLA General Hospital, Beijing, China
    Juan Chen, School of Nursing and Public Health, Yangzhou University, Beijing, China
    Zhengyang Hou, Department of Social Management and Social Policy, School of Social Development and Public Policy, Fudan University, Shanghai, 200433, Shanghai Municipality, China
    Shuai Jin, Department of Medical Oncology, Senior Department of Oncology, The Fifth Medical Center of PLA General Hospital, Beijing, China
    Haitao Tao, Department of Medical Oncology, Senior Department of Oncology, The Fifth Medical Center of PLA General Hospital, Beijing, China
    Heying Yu, Department of Medical Oncology, The Third Medical Center of PLA General Hospital, Beijing, China
    Jiapei Qin, Department of Medical Oncology, Senior Department of Oncology, The Fifth Medical Center of PLA General Hospital, Beijing, China
    Mingzhen Zhu, Department of Thoracic Surgery, Affiliated Hospital of Jining Medical University, Jining, China
    Yi Hu, Department of Medical Oncology, Senior Department of Oncology, The Fifth Medical Center of PLA General Hospital, Beijing, China
    Zhefeng Liu, Department of Medical Oncology, Senior Department of Oncology, The Fifth Medical Center of PLA General Hospital, Beijing, China

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