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BRIEF RESEARCH REPORT article

Front. Psychiatry
Sec. Psychological Therapy and Psychosomatics
Volume 15 - 2024 | doi: 10.3389/fpsyt.2024.1282172

Depression and the Risk of Fibromyalgia Syndrome: A Two-Sample Mendelian Randomization Study

Provisionally accepted
Xiaoshan Ma Xiaoshan Ma 1Jing Sun Jing Sun 2*Ren Geng Ren Geng 1Yao Zhao Yao Zhao 1Wanzhen Xu Wanzhen Xu 1Yining Jiang Yining Jiang 1Liyan Zhao Liyan Zhao 3*Yunqian Li Yunqian Li 1*
  • 1 Department of Neurosurgery, First Affiliated Hospital of Jilin University, Changchun, Hebei Province, China
  • 2 Department of Anesthesiology, First Affiliated Hospital of Jilin University, Changchun, Hebei Province, China
  • 3 Department of Blood Transfusion, Second Hospital of Jilin University, Changchun, Hebei Province, China

The final, formatted version of the article will be published soon.

    Background: Fibromyalgia is a common illness with a wide range of symptoms, mainly manifested by unexplained chronic systemic musculoskeletal pain, sleep disorders and fatigue, sometimes accompanied by cognitive impairment, psychiatric symptoms and autonomic dysfunction. Previous studies have indicated a correlation between depression and the risk of FM; however, it remains uncertain whether this association reflects a causal relationship. Methods: We evaluated the etiological association between the genetically predicted depression and the risk of developing FM by conducting a two-sample Mendelian Randomization (MR) study. The data on single nucleotide polymorphisms (SNPs) related to depression were obtained from the UK Biobank (UKB) and the Psychiatric Genomics Consortium (PGC) of White British European ancestry, and the data for FM were from the 5th release of the FinnGen study. We adopted the Inverse Variance Weighted (IVW) approach as the principal standard. In order to detect the existence of horizontal pleiotropy and heterogeneity, we adopted the MR-Egger approach as the sensitivity analysis. Results: In our MR analysis, 42 depression-related variants were identified as valid instrumental variables (IVs). The IVW approach's results manifest that there is no etiologic causality between genetically predicted depression and the risk of FM (odds ratio [OR]: 1.673, 95% confidence interval [CI]: 0.852—3.287, P = 0.135). The study did not find any significant heterogeneities or horizontal pleiotropies (P > 0.05). Conclusions: Our results suggest that there is no significant genetic evidence linking depression to an increased risk of FM.

    Keywords: Depression, Fibromyalgia, Single nucleotide polymorphism, risk, Mendelian Randomization Analysis

    Received: 28 Sep 2023; Accepted: 14 Oct 2024.

    Copyright: © 2024 Ma, Sun, Geng, Zhao, Xu, Jiang, Zhao and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jing Sun, Department of Anesthesiology, First Affiliated Hospital of Jilin University, Changchun, Hebei Province, China
    Liyan Zhao, Department of Blood Transfusion, Second Hospital of Jilin University, Changchun, Hebei Province, China
    Yunqian Li, Department of Neurosurgery, First Affiliated Hospital of Jilin University, Changchun, Hebei Province, China

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