AUTHOR=Zhu Xianlin , Zhao Yiwen , Li Lu , Liu Jiaoying , Huang Qiankun , Wang Suhong , Shu Yanping 

TITLE=Association of non-HDL-C and depression: a cross-sectional analysis of the NHANES data

JOURNAL=Frontiers in Psychiatry

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2023.1274648

DOI=10.3389/fpsyt.2023.1274648

ISSN=1664-0640

ABSTRACT=<sec id="sec1"><title>Objectives</title><p>Non-high-density lipoprotein cholesterol (non-HDL-C) has attracted attention because it is associated with a variety of diseases and is easy to measure. However, the relationship between non-HDL-C and depression is still unclear. Our aim was to assess the relationship between non-HDL-C and depression using the cross-sectional NHANES survey from 2005 to 2018.</p></sec><sec id="sec2"><title>Methods</title><p>We examined the association between non-HDL-C and depression using weighted multivariable logistic regression models and subgroup analysis. Sensitivity analysis demonstrated the robustness of the results.</p></sec><sec id="sec3"><title>Results</title><p>There were 42,143 participants in this study and 8.6% had depression (weighted 7.53%). Non-HDL-C was higher in participants with depression compared to those without depression (weighted mean 3.64 vs. 3.73, <italic>p</italic> &lt; 0.01). There was a positive association between non-HDL-C and depression with a 95% OR of 1.22 adjusted for multifactorial (95% CI,1.03–1.45). In subgroup analyses, non-HDL-C was positively associated with depression in men (OR, 1.31; 95% CI, 1.01–1.70), normal BMI (OR: 0.93; 95% CI: 0.66–1.32) and in participants without hypertension (OR, 1.29; 95% CI, 1.01–1.66).</p></sec><sec id="sec4"><title>Conclusion</title><p>Non-HDL-C positively correlated with depression, and further research may be better for clinical service.</p></sec>