AUTHOR=Moreira Lorrane K. S. , Moreira Caroline V. L. , Custódio Carlos H. X. , Dias Matheus L. P. , Rosa Daniel A. , Ferreira-Neto Marcos L. , Colombari Eduardo , Costa Elson A. , Fajemiroye James O. , Pedrino Gustavo R. 

TITLE=Post-partum depression: From clinical understanding to preclinical assessments

JOURNAL=Frontiers in Psychiatry

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2023.1173635

DOI=10.3389/fpsyt.2023.1173635

ISSN=1664-0640

ABSTRACT=<p>Post-partum depression (PPD) with varying clinical manifestations affecting new parents remains underdiagnosed and poorly treated. This minireview revisits the pharmacotherapy, and relevant etiological basis, capable of advancing preclinical research frameworks. Maternal tasks accompanied by numerous behavioral readouts demand modeling different paradigms that reflect the complex and heterogenous nature of PPD. Hence, effective PPD-like characterization in animals towards the discovery of pharmacological intervention demands research that deepens our understanding of the roles of hormonal and non-hormonal components and mediators of this psychiatric disorder.</p>