AUTHOR=Yin Xiaowen , Chen Song , Ju Xuan , Hu Xiwen TITLE=Case report: Treatment-resistant depression with acute psychosis in an adolescent girl with Cushing's syndrome JOURNAL=Frontiers in Psychiatry VOLUME=14 YEAR=2023 URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2023.1170890 DOI=10.3389/fpsyt.2023.1170890 ISSN=1664-0640 ABSTRACT=

Cushing's syndrome (CS) is a rare disease with multiple somatic signs and a high prevalence of co-occurring depression. However, the characteristics of depression secondary to CS and the differences from major depression have not been described in detail. In this case, we report a 17-year-old girl with treatment-resistant depression with a series of atypical features and acute psychotic episodes, which is a rare condition secondary to CS. This case showed a more detailed profile of depression secondary to CS and highlighted the differences with major depression in clinical features, and it will improve insight into the differential diagnosis especially when the symptoms are not typical.