AUTHOR=Wu Yuyu , Zhao Ke , Chen Yingjie , Wu Liujun , Qiu Feng , Yuan Yuying , Shen Guanghui , Wang Kexin , Kang Yimin , Jiang Yongsheng , Wang Wei , Chen Li , Liu Yanlong , Pan Xuebo , Wang Fan , Xie Longteng
TITLE=The interaction between the major vault protein rs4788186 polymorphism, alcohol dependence, and depression among male Chinese problem drinkers
JOURNAL=Frontiers in Psychiatry
VOLUME=14
YEAR=2023
URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2023.1111712
DOI=10.3389/fpsyt.2023.1111712
ISSN=1664-0640
ABSTRACT=ObjectiveAlcohol use disorder (AUD) is the second most prevalent mental disorder and might be related to depression. Major vault protein (MVP) is a cytoplasmic protein related to vesicle transport. The present study aimed to investigate the interaction between a genetic variant (MVP rs4788186) and depression in adult male Han Chinese with AUD during withdrawal.
MethodsAll participants (N = 435) were diagnosed with AUD. Alcohol dependence level was measured using the Michigan Alcoholism Screening Test, and depression was measured using the self-rating depression scale. Genomic DNA was extracted from peripheral blood and genotyped.
ResultsHierarchical regression analysis identified an interaction between MVP rs4788186 and alcohol dependence level for depression (β = −0.17, p < 0.05). Then, a region of significance test was performed to interpret the interaction effect. Re-parameterized regression models revealed that the interaction between MVP rs4788186 and alcohol problem severity fit the strong differential susceptibility model (R2 = 0.08, p < 0.001), suggesting that the AA homozygotes would be more likely subjects with the G allele to experience major depression symptoms.
ConclusionCarriers of the AA homozygote of MVP rs4788186 may be more susceptible to severe alcohol problems and higher levels of depression during withdrawal.