AUTHOR=Sun Yang , Zhao Jing , Zhao PanWen , Zhang Hui , Zhong JianGuo , Pan PingLei , Wang GenDi , Yi ZhongQuan , Xie LiLi 

TITLE=Social cognition in children and adolescents with epilepsy: A meta-analysis

JOURNAL=Frontiers in Psychiatry

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2022.983565

DOI=10.3389/fpsyt.2022.983565

ISSN=1664-0640

ABSTRACT=<p>Many studies have investigated impairments in two key domains of social cognition (theory of mind [ToM] and facial emotion recognition [FER]) in children and adolescents with epilepsy. However, inconsistent conclusions were found. Our objective was to characterize social cognition performance of children and adolescents with epilepsy. A literature search was conducted using Web of Science, PubMed, and Embase databases. The article retrieval, screening, quality assessment (Newcastle-Ottawa-Scale), and data extraction were performed independently by two investigators. A random-effects model was used to examine estimates. The meta-analysis included 19 studies, with a combined sample of 623 children and adolescents with epilepsy (mean [SD] age, 12.13 [2.62] years; 46.1% female) and 677 healthy controls [HCs]) (mean [SD] age, 11.48 [2.71] years; 50.7% female). The results revealed that relative to HCs, children and adolescents with epilepsy exhibited deficits in ToM (<italic>g</italic> = −1.08, 95% <italic>CI</italic> [−1.38, −0.78], <italic>p</italic> &lt; 0.001, the number of studies [<italic>k</italic>] = 13), FER (<italic>g</italic> = −0.98, 95% <italic>CI</italic> [−1.33, −0.64], <italic>p</italic> &lt; 0.001, <italic>k</italic> = 12), and ToM subcomponents (cognitive ToM: <italic>g</italic> = −1.04, 95% <italic>CI</italic> [−1.35, −0.72], <italic>p</italic> &lt; 0.001, <italic>k</italic> = 12] and affective ToM: <italic>g</italic> = −0.73, 95% <italic>CI</italic> [−1.12, −0.34], <italic>p</italic> &lt; 0.001, <italic>k</italic> = 8). In addition, there were no statistically significant differences in social cognition deficits between children and adolescents with focal epilepsy and generalized epilepsy. Meta-regressions confirmed the robustness of the results. These quantitative results further deepen our understanding of the two core domains of social cognition in children and adolescents with epilepsy and may assist in the development of cognitive interventions for this patient population.</p><p><bold>Systematic review registration:</bold><ext-link ext-link-type="uri" xlink:href="https://inplasy.com/inplasy-2022-3-0011/" xmlns:xlink="http://www.w3.org/1999/xlink">https://inplasy.com/inplasy-2022-3-0011/</ext-link>, identifier INPLASY202230011.</p>