AUTHOR=Zahid Uzma , McCutcheon Robert A. , Borgan Faith , Jauhar Sameer , Pepper Fiona , Nour Matthew M. , Rogdaki Maria , Osugo Martin , Murray Graham K. , Hathway Pamela , Murray Robin M. , Egerton Alice , Howes Oliver D. 

TITLE=The effect of antipsychotics on glutamate levels in the anterior cingulate cortex and clinical response: A 1H-MRS study in first-episode psychosis patients

JOURNAL=Frontiers in Psychiatry

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2022.967941

DOI=10.3389/fpsyt.2022.967941

ISSN=1664-0640

ABSTRACT=<sec><title>Introduction</title><p>Glutamatergic dysfunction is implicated in the pathophysiology of schizophrenia. It is unclear whether glutamatergic dysfunction predicts response to treatment or if antipsychotic treatment influences glutamate levels. We investigated the effect of antipsychotic treatment on glutamatergic levels in the anterior cingulate cortex (ACC), and whether there is a relationship between baseline glutamatergic levels and clinical response after antipsychotic treatment in people with first episode psychosis (FEP).</p></sec><sec><title>Materials and methods</title><p>The sample comprised 25 FEP patients; 22 completed magnetic resonance spectroscopy scans at both timepoints. Symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS).</p></sec><sec><title>Results</title><p>There was no significant change in glutamate [baseline 13.23 ± 2.33; follow-up 13.89 ± 1.74; t(21) = −1.158, <italic>p</italic> = 0.260], or Glx levels [baseline 19.64 ± 3.26; follow-up 19.66 ± 2.65; t(21) = −0.034, <italic>p</italic> = 0.973]. There was no significant association between glutamate or Glx levels at baseline and the change in PANSS positive (Glu <italic>r</italic> = 0.061, <italic>p</italic> = 0.777, Glx <italic>r</italic> = −0.152, <italic>p</italic> = 0.477), negative (Glu <italic>r</italic> = 0.144, <italic>p</italic> = 0.502, Glx <italic>r</italic> = 0.052, <italic>p</italic> = 0.811), general (Glu <italic>r</italic> = 0.110, <italic>p</italic> = 0.607, Glx <italic>r</italic> = −0.212, <italic>p</italic> = 0.320), or total scores (Glu <italic>r</italic> = 0.078, <italic>p</italic> = 0.719 Glx <italic>r</italic> = −0.155, <italic>p</italic> = 0.470).</p></sec><sec><title>Conclusion</title><p>These findings indicate that treatment response is unlikely to be associated with baseline glutamatergic metabolites prior to antipsychotic treatment, and there is no major effect of antipsychotic treatment on glutamatergic metabolites in the ACC.</p></sec>