AUTHOR=Shen Liang , Chen Jia-qi , Yang Xin-lu , Hu Ji-cheng , Gao Wei , Chai Xiao-qing , Wang Di 

TITLE=Flurbiprofen used in one-lung ventilation improves intraoperative regional cerebral oxygen saturation and reduces the incidence of postoperative delirium

JOURNAL=Frontiers in Psychiatry

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2022.889637

DOI=10.3389/fpsyt.2022.889637

ISSN=1664-0640

ABSTRACT=<sec><title>Background</title><p>We previously demonstrated that flurbiprofen increased arterial oxygen partial pressure and reduced intrapulmonary shunts. The present study aims to investigate whether flurbiprofen improves intraoperative regional cerebral oxygen saturation (rScO<sub>2</sub>) and reduces the incidence of postoperative delirium (POD) in elderly patients undergoing one-lung ventilation (OLV).</p></sec><sec><title>Methods</title><p>One hundred and twenty patients undergoing thoracoscopic lobectomy were randomly assigned to the flurbiprofen-treated group (<italic>n</italic> = 60) and the control-treated group (<italic>n</italic> = 60). Flurbiprofen was intravenously administered 20 minutes before skin incision. The rScO<sub>2</sub> and partial pressure of arterial oxygen (PaO<sub>2</sub>) were recorded during the surgery, and POD was measured by the Confusion Assessment Method (CAM) within 5 days after surgery. The study was registered in the Chinese Clinical Trial Registry with the number ChiCTR1800020032.</p></sec><sec><title>Results</title><p>Compared with the control group, treatment with flurbiprofen significantly improved the mean value of intraoperative rScO<sub>2</sub> as well as the PaO<sub>2</sub> value (P &lt; 0.05, both) and significantly reduced the baseline values of the rScO<sub>2</sub> area under threshold (AUT) (<italic>P</italic> &lt; 0.01) at 15, 30, and 60 min after OLV in the flurbiprofen-treated group. After surgery, the POD incidence in the flurbiprofen-treated group was significantly decreased compared with that in the control group (<italic>P</italic> &lt; 0.05).</p></sec><sec><title>Conclusion</title><p>Treatment with flurbiprofen may improve rScO<sub>2</sub> and reduce the incidence of POD in elderly patients undergoing thoracoscopic one-lung ventilation surgery for lung cancer.</p></sec><sec><title>Clinical trial registration</title><p><ext-link ext-link-type="uri" xlink:href="http://www.chictr.org/cn/" xmlns:xlink="http://www.w3.org/1999/xlink">http://www.chictr.org/cn/</ext-link>, identifier ChiCTR1800020032.</p></sec>