AUTHOR=Zhong Junfeng , Li Yan , Fang Lichao , Han Dan , Gong Chuhao , Hu Shuangyan , Wang Rongguo , Wang Liwei , Yao Rui , Li Beiping , Zhu Yangzi , Yu Youjia 

TITLE=Effects of Sevoflurane and Propofol on Posttraumatic Stress Disorder After Emergency Trauma: A Double-Blind Randomized Controlled Trial

JOURNAL=Frontiers in Psychiatry

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2022.853795

DOI=10.3389/fpsyt.2022.853795

ISSN=1664-0640

ABSTRACT=<sec><title>Objective</title><p>Posttraumatic stress disorder (PTSD) is a frequent and disabling consequence of traumatic events. A previous study found that early use of propofol was a potential risk factor for PTSD. This prospective study aimed to investigate the effect of propofol and sevoflurane on PTSD after emergency surgery in trauma patients.</p></sec><sec><title>Methods</title><p>A total of 300 trauma patients undergoing emergency surgery were randomly divided into two groups and anesthetized with propofol and/or sevoflurane. Perioperative clinical data were collected. The incidence of PTSD was evaluated with the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) in the two groups 1 month after the operation. The relevance of the injury time and CAPS-5 scores was assessed by Spearman correlation analysis. Logistic regression analysis was used to analyze the risk factors for PTSD.</p></sec><sec><title>Results</title><p>The incidence of PTSD in the propofol group was higher than that in the sevoflurane group 1 month postoperatively (23.2 vs. 12.2%, <italic>P</italic> = 0.014). The injury time was negatively correlated with the CAPS-5 score in the propofol group (<italic>r</italic> = <italic>-</italic>0.226<italic>, P</italic> &lt; 0.001). In the logistic regression analysis, the utilization of propofol was an independent risk factor for PTSD (<italic>P</italic> = 0.017).</p></sec><sec><title>Conclusion</title><p>Early use of propofol general anesthesia in emergency surgery for trauma patients may increase the risk of PTSD.</p></sec><sec><title>Clinical Trial Registration</title><p><ext-link ext-link-type="uri" xlink:href="http://www.chictr.org.cn" xmlns:xlink="http://www.w3.org/1999/xlink">www.chictr.org.cn</ext-link>, identifier: ChiCTR2100050202.</p></sec>