AUTHOR=Li Xiaoli , Zhou Ping , Li Qiu , Peng Bin , Cun Yupeng , Dai Ying , Wei Hua , Liu Xiao , Yu Yang , Jiang Zhiyang , Fan Qiongli , Zhang Yuping , Yang Ting , Chen Jie , Cheng Qian , Li Tingyu , Chen Li TITLE=Regressive Autism Spectrum Disorder: High Levels of Total Secreted Amyloid Precursor Protein and Secreted Amyloid Precursor Protein-α in Plasma JOURNAL=Frontiers in Psychiatry VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2022.809543 DOI=10.3389/fpsyt.2022.809543 ISSN=1664-0640 ABSTRACT=
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by social communication difficulties, repetitive behaviors, and parochial interests. Individuals with regressive ASD (RA), a unique subtype, have poor outcomes. Moreover, there are currently no validated blood-based biomarkers for ASD, hindering early diagnosis and treatment. This study was the first to examine plasma levels of total secreted amyloid precursor protein (sAPPtotal), secreted amyloid precursor protein-α (sAPPα), and secreted amyloid precursor protein-β (sAPPβ) in children diagnosed with RA (