AUTHOR=Wang Jianjun , Gong Shenglan , Kong Fanxin , Cai Dongbin , Huang Binqing , Zheng Haotao , Lin Songjun , Li Jinfang , Zhang Tianfeng 

TITLE=Psychotic Symptoms as the Initial Presentation of a Long-Lasting Misdiagnosed Anti-GAD65 Autoimmune Encephalitis: An Emblematic Case and Literature Review

JOURNAL=Frontiers in Psychiatry

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2022.754938

DOI=10.3389/fpsyt.2022.754938

ISSN=1664-0640

ABSTRACT=<sec><title>Objective</title><p>To present a long-lasting misdiagnosed case of anti-GAD65 autoimmune encephalitis (AE) and promote the early identification of reversible psychotic symptoms in AE.</p></sec><sec><title>Methods</title><p>The case report was generated through detailed assessment of clinical characteristics, cerebral magnetic resonance images, and laboratory results. Meanwhile, a literatures review related to the topic was conducted.</p></sec><sec><title>Results</title><p>Psychotic symptoms could be presented in the early stage of anti-GAD65 autoimmune encephalitis. Even though there exists a transdisciplinary gap that hinder the timely recognition of early psychiatric symptoms as components of organic disease, a few strategies could be introduced to enable the earlier recognition and appropriate treatment.</p></sec><sec><title>Conclusions</title><p>Our report intends to raise awareness to promote the early identification of immune-mediated “symptomatic” forms of psychosis.</p></sec>