AUTHOR=Yan Xiu , Xu Peiwei , Sun Xueli 

TITLE=Circadian rhythm disruptions: A possible link of bipolar disorder and endocrine comorbidities

JOURNAL=Frontiers in Psychiatry

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2022.1065754

DOI=10.3389/fpsyt.2022.1065754

ISSN=1664-0640

ABSTRACT=<p>Epidemiological studies have demonstrated an association between bipolar disorder (BP) and endocrine diseases. Further, circadian rhythm disruptions may be a potential common pathophysiological mechanism of both disorders. This review provides a brief overview of the molecular mechanisms of circadian rhythms, as well as roles circadian rhythms play in BP and common endocrine comorbidities such as diabetes and thyroid disease. Treatments targeting the circadian system, both pharmacological and non-pharmacological, are also discussed. The hope is to elicit new interest to the importance of circadian system in BP and offer new entry points and impetus to the development of medicine.</p>