AUTHOR=Nie Li , Pan Xian-li , Zhang Xiao-bao , Zhang Shan , Rao Ji-Xian , Su Zeng-feng 

TITLE=Research on the correlation of immunity in patients with chronic insomnia

JOURNAL=Frontiers in Psychiatry

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2022.1034405

DOI=10.3389/fpsyt.2022.1034405

ISSN=1664-0640

ABSTRACT=<sec><title>Purpose</title><p>To investigate the changes in immunity and clinical infection events among patients with chronic insomnia.</p></sec><sec><title>Materials and methods</title><p>Forty-two patients with chronic insomnia (age = 64.44 ± 10.53) and 47 normal controls (age = 67.08 ± 7.822) were selected to determine differences in data, such as complete blood counts (CBCs), biochemical indices, lymphocyte subsets, immunoglobulin (Ig), complement C3 and C4 and interleukin-6 (IL-6), as well as to compare the incidence of clinical infection between the two groups.</p></sec><sec><title>Results</title><p>There were significant differences in erythrocyte, hemoglobin, hematocrit, albumin, globulin, creatinine, IgG, IgG/IgM ratio, CD4<sup>+</sup> T-lymphocytes, CD19-lymphocytes, CD4<sup>+</sup>/CD8<sup>+</sup> ratio, platelet/lymphocyte ratio, CD19/CD3 ratio, and clinical infection events between the chronic insomnia group and the control group (<italic>p</italic> &lt; 0.05). There was no significant difference in neutrophil, lymphocyte, monocyte, and platelet counts; lymphocyte subsets CD8<sup>+</sup> T and CD56<sup>+</sup>; platelet-to-lymphocyte ratio (PLR); neutrophil-to-lymphocyte ratio (NLR); complement C3; complement C4; IgM; IgA; and IL-6 between the experimental group and their controls (<italic>p</italic> &gt; 0.05). The systolic and diastolic blood pressures of the chronic insomnia group did not vary widely from those of the controls (<italic>p</italic> &gt; 0.05).</p></sec><sec><title>Conclusion</title><p>Patients with chronic insomnia have immunological abnormalities, characterized by a higher incidence of clinical infection.</p></sec>