AUTHOR=Takaesu Yoshikazu , Kanda Yuta , Nagahama Yu , Shiroma Ayano , Ishii Miho , Hashimoto Tasuku , Watanabe Koichiro 

TITLE=Delayed sleep-wake rhythm is associated with cognitive dysfunction, social dysfunction, and deteriorated quality of life in patients with major depressive disorder

JOURNAL=Frontiers in Psychiatry

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2022.1022144

DOI=10.3389/fpsyt.2022.1022144

ISSN=1664-0640

ABSTRACT=<sec><title>Background</title><p>The delayed sleep-wake phase is commonly observed in major depressive disorder (MDD) and thought to be associated with functional impairments. This study aimed to evaluate the relationship between the delayed sleep-wake phase, cognitive dysfunction, social dysfunction, and quality of life in patients with MDD.</p></sec><sec><title>Methods</title><p>This cross-sectional design included 33 outpatients with MDD. Objective sleep-wake rhythm was assessed by actigraphy. Functional impairments were evaluated by the Japanese version of the Brief Assessment of Cognition in Schizophrenia (BACS-J), World Health Organization Disability Assessment Schedule (WHO-DAS), and Euro QOL 5 dimensions (EQ5D).</p></sec><sec><title>Results</title><p>Actigraphic assessment of the delayed sleep-wake phase (midpoint of sleep) was significantly correlated with the composite score of the BACS-J (<italic>r</italic> = –0.489, <italic>p</italic> = 0.010), WHO-DAS score (<italic>r</italic> = 0.466, <italic>p</italic> = 0.014), and EQ5D score (<italic>r</italic> = 0.472, <italic>p</italic> = 0.013). No significant correlation was found between the other actigraphic sleep parameters (sleep latency, total sleep time, and sleep efficiency) and functional impairments.</p></sec><sec><title>Conclusion</title><p>Our study’s results suggested that the delayed sleep-wake phase is associated with cognitive dysfunction, social dysfunction, and deteriorated quality of life in patients with MDD. Clinicians should pay attention to the sleep-wake rhythm in patients with MDD in clinical settings.</p></sec>