AUTHOR=Hu Baiqi , Liu Chunyan , Mou Tingting , Luo Fangyi , Lv Tingting , Qian Chao , Zhang Jian , Ye Mengfei , Liu Zheng 

TITLE=Meta-Analysis of Sleep Deprivation Effects on Patients With Depression

JOURNAL=Frontiers in Psychiatry

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2021.783091

DOI=10.3389/fpsyt.2021.783091

ISSN=1664-0640

ABSTRACT=<p><bold>Objective:</bold> Depression is a common disorder with a high recurrence rate. Since the effect of sleep deprivation on depression in existing studies were inconsistent, the present study aimed to reassess the effects of SD on patients by performing a meta-analysis of updated research.</p><p><bold>Methods:</bold> PubMed, Embase, the Cochrane Library, and Web of Science were searched for articles before January 20th, 2021. Data on participant characteristics, SD characteristics, adjunctive method and tests for depression were extracted. A comprehensive analysis was conducted to assess the effect of SD on depression and subgroup analysis was used to determine the sources of heterogeneity.</p><p><bold>Results:</bold> In total, 8 articles were included. An SD time of &lt;7 days slightly worsened depression levels [0.24 (−0.21, 0.69); <italic>I</italic><sup>2</sup> = 0%; <italic>P</italic> = 0.43], a time of 7–14 days had antidepressant effects [−1.52 (−2.07, −0.97); <italic>I</italic><sup>2</sup> = 19.6%; <italic>P</italic> = 0.288], and a time of more than 14 days also worsened depression [0.76 (0.12, 1.40); <italic>I</italic><sup>2</sup> = 43.7%; <italic>P</italic> = 0.169].</p><p><bold>Conclusion:</bold> SD may serve as an effective antidepressant measure in humans when the time was 7–14 days, while a time of &lt;7 days and more than 14 days worsened depression.</p>