AUTHOR=Kang Hee-Ju , Kim Ju-Wan , Lee Ju-Yeon , Kim Sung-Wan , Shin Il-Seon , Hong Young Joon , Ahn Youngkeun , Jeong Myung-Ho , Kim Jae-Min 

TITLE=Time-Specific Associations of Tumor Necrosis Factor-α Levels and Polymorphisms (−850 C/T or −308 G/A) With Suicidal Ideation in Acute Coronary Syndrome Patients

JOURNAL=Frontiers in Psychiatry

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2021.739823

DOI=10.3389/fpsyt.2021.739823

ISSN=1664-0640

ABSTRACT=<p><bold>Background:</bold> Considering the association of inflammation with suicide and acute coronary syndrome (ACS), we investigated the individual and interactive effects of serum tumor necrosis factor-alpha (sTNFα) levels and two polymorphisms (−850 <italic>C</italic>/<italic>T</italic> and −308 <italic>G</italic>/<italic>A</italic>) on suicidal ideation (SI) after ACS.</p><p><bold>Methods:</bold> The SI status using items on the Montgomery–Åsberg Depression Rating Scale (MADRS), related covariates including sociodemographic and clinical characteristics, sTNFα levels, and tumor necrosis factor-alpha (TNF-α) polymorphisms were evaluated in 969 patients within 2 weeks after ACS. Of the patients, 711 were evaluated 1 year later for SI. Multivariate logistic regression models were used to calculate individual and interactive associations after adjusting for the covariates.</p><p><bold>Results:</bold> Higher (vs. lower) sTNFα levels and the −<italic>850 C</italic>/<italic>T</italic> or <italic>T/T</italic> (vs. C/C) polymorphism were significantly associated with SI 2 weeks after ACS, while only higher sTNFα levels were significantly associated with SI after 1 year. Significant interactive effects were detected between sTNFα (higher) levels and the −<italic>850 C/T (C/C</italic> or <italic>C/T)</italic> polymorphism on SI 2 weeks after ACS and between the two (−850 <italic>CC</italic> or <italic>CT</italic> and −<italic>308 G/A</italic> or <italic>AA</italic>) polymorphisms on SI 1 year after ACS.</p><p><bold>Conclusions:</bold> The sTNFα level and two polymorphisms (−850C/<italic>T</italic> and −308 <italic>G/A</italic>), separately or in combination, could be time-specific biomarkers for SI in ACS. Focused interventions for ACS patients at risk of SI might reduce the suicidal burden in patients with ACS.</p>