AUTHOR=Sun Yajing , Qu Yuanyuan , Zhu Jianwei 

TITLE=The Relationship Between Inflammation and Post-traumatic Stress Disorder

JOURNAL=Frontiers in Psychiatry

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2021.707543

DOI=10.3389/fpsyt.2021.707543

ISSN=1664-0640

ABSTRACT=<p><bold>Background:</bold> Stress disorders, such as post-traumatic stress disorder (PTSD), are attracting much attention. However, the relationship between traumatic stress and inflammation is rarely discussed.</p><p><bold>Subjects and Methods:</bold> As studies have linked PTSD to altered susceptibility to various diseases, such a psychiatric condition may lead to long-term systematic changes in physiological functions. We searched PubMed with the keywords “traumatic stress,” “stress disorders,” “post-traumatic stress disorder,” and “inflammation.”</p><p><bold>Results:</bold> Based on 65 previously published studies, we reviewed the long-term effects of PTSD, as well as traumatic events, on inflammatory function from both epidemiological and biological perspectives. Post-traumatic stress disorder is related to the immune response, including an increase in inflammatory factors and a reduction in anti-inflammatory factors. Additionally, it has been demonstrated that traumatic stress disorder and immune disease share a common genetic basis at the gene expression level.</p><p><bold>Conclusions:</bold> Understanding this relationship is of great significance for optimizing treatment plans for patients with PTSD.</p>