AUTHOR=Zhang Tianran , Wang Lanlan , Bai Yanle , Zhao Wenqing , Wu Yanru , Jiang Wenhui , Fan Qing , Qiu Jianyin 

TITLE=Mindfulness-Based Cognitive Therapy in Major Depressive Disorder: A Study Protocol of a Randomized Control Trial and a Case–Control Study With Electroencephalogram

JOURNAL=Frontiers in Psychiatry

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2021.499633

DOI=10.3389/fpsyt.2021.499633

ISSN=1664-0640

ABSTRACT=<p><bold>Background:</bold> In this report, a study protocol for a randomized control trial is presented in an attempt to explore the efficacy of mindfulness-based cognitive therapy (MBCT) for major depressive disorder (MMD), and a case–control study is conducted to find the difference in electroencephalograms (EEGs) between MMD and normal controls.</p><p><bold>Design:</bold> Seventy Chinese patients with MMD will be chosen for random division in the MBCT group or medication group, with half of the participants receiving common medication treatment [selective serotonin reuptake inhibitors (SSRIs)] and half receiving MBCT as a supplement to the common medication treatment. All participants, namely, 70 MMD cases and 35 matched normal controls, will be tested by a range of scales and EEG at baseline (week 0), mid-intervention (weeks 2, 4, and 6), post-intervention (week 8), and 6-months follow-up (weeks 12, 20, and 32).</p><p><bold>Discussion:</bold> The findings of this study will provide a positive reference for the treatment of depression and future research on MBCT treatment mechanism.</p><p><bold>Trial Registration:</bold> NCT03558256. Registered: June 13, 2018—retrospectively registered, <ext-link ext-link-type="uri" xlink:href="https://clinicaltrials.gov/ct2/show/NCT03558256" xmlns:xlink="http://www.w3.org/1999/xlink">https://clinicaltrials.gov/ct2/show/NCT03558256</ext-link>.</p>