AUTHOR=Alnefeesi Yazen , Siegel Ashley , Lui Leanna M. W. , Teopiz Kayla M. , Ho Roger C. M. , Lee Yena , Nasri Flora , Gill Hartej , Lin Kangguang , Cao Bing , Rosenblat Joshua D. , McIntyre Roger S. TITLE=Impact of SARS-CoV-2 Infection on Cognitive Function: A Systematic Review JOURNAL=Frontiers in Psychiatry VOLUME=11 YEAR=2021 URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2020.621773 DOI=10.3389/fpsyt.2020.621773 ISSN=1664-0640 ABSTRACT=
The prevalence and etiology of COVID-19's impact on brain health and cognitive function is poorly characterized. With mounting reports of delirium, systemic inflammation, and evidence of neurotropism, a statement on cognitive impairment among COVID-19 cases is needed. A substantial literature has demonstrated that inflammation can severely disrupt brain function, suggesting an immune response, a cytokine storm, as a possible cause of neurocognitive impairments. In this light, the aim of the present study was to summarize the available knowledge of the impact of COVID-19 on cognition (i.e., herein, we broadly define cognition reflecting the reporting on this topic in the literature) during the acute and recovery phases of the disease, in hospitalized patients and outpatients with confirmed COVID-19 status. A systematic review of the literature identified six studies which document the prevalence of cognitive impairment, and one which quantifies deficits after recovery. Pooling the samples of the included studies (total sample