AUTHOR=Hinney Bernd , Walter Anna , Aghlmandi Soheila , Andreou Christina , Borgwardt Stefan 

TITLE=Does Hippocampal Volume Predict Transition to Psychosis in a High-Risk Group? A Meta-Analysis

JOURNAL=Frontiers in Psychiatry

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2020.614659

DOI=10.3389/fpsyt.2020.614659

ISSN=1664-0640

ABSTRACT=<p>Schizophrenia has a prodromal phase of several years in most patients, making it possible to identify patients at clinical high risk (CHR) for developing the disorder. So far, these individuals are identified based on clinical criteria alone, and there is no reliable biomarker for predicting the transition to psychosis. It is well-established that reductions in brain volume, especially in the hippocampus, are associated with schizophrenia. Therefore, hippocampal volume may serve as a biomarker for psychosis. Several studies have already investigated hippocampal volume in CHR groups. Based on these studies, the present meta-analysis compares the baseline left and right hippocampal volume of CHR patients who developed a psychosis with that of CHR patients without such a transition. Our results show no statistically significant effect of the hippocampal volume on the transition risk for psychosis.</p>