AUTHOR=Kong Xuejun , Zhu Junli , Tian Ruiyi , Liu Siyu , Sherman Hannah T. , Zhang Xiaoying , Lin Xiaojing , Han Yan , Xiang Zhi , Koh Madelyn , Hobbie Clara , Wang Bryan , Liu Kevin , Liu Jun , Yin Yueping , Wan Guobin 

TITLE=Early Screening and Risk Factors of Autism Spectrum Disorder in a Large Cohort of Chinese Patients With Prader-Willi Syndrome

JOURNAL=Frontiers in Psychiatry

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2020.594934

DOI=10.3389/fpsyt.2020.594934

ISSN=1664-0640

ABSTRACT=<p>Previous studies regarding the prevalence of Autism Spectrum Disorder (ASD) in patients with Prader-Willi Syndrome (PWS) have implicated heterogenous findings. Additionally, the early screening of ASD high-risk population for ASD and identifying ASD risk factors in PWS patients have not been explored. This study included 218 Chinese PWS patients aged 3 months to 18 years old. 78% of subjects were identified as high risk for ASD by ASQ-3 Communication domain score for those younger than 3 years of age and 84% of subjects were classified as high risk for ASD by the GARS-3 for those aged 3 years and older. Among PWS clinical measurements, under-height (<italic>P</italic> = 0.0186), overweight (<italic>P</italic> = 0.0248), and obstructive sleep apnea (<italic>P</italic> = 0.0259) were each significantly correlated with ASD risk. These risk factors and their internal relationship with ASD or ASD traits warrant further studies.</p>