AUTHOR=García Saínza , Gorostegi-Anduaga Ilargi , García-Corres Edurne , Maldonado-Martín Sara , MacDowell Karina S. , Bermúdez-Ampudia Cristina , Apodaca María J. , Pérez-Landaluce Irene , Tobalina-Larrea Ignacio , Leza Juan C. , González-Pinto A.
TITLE=Functionality and Neurocognition in Patients With Bipolar Disorder After a Physical-Exercise Program (FINEXT-BD Study): Protocol of a Randomized Interventionist Program
JOURNAL=Frontiers in Psychiatry
VOLUME=11
YEAR=2020
URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2020.568455
DOI=10.3389/fpsyt.2020.568455
ISSN=1664-0640
ABSTRACT=Introduction: Recent studies have shown that symptoms of psychiatric illness, functionality, and cognitive function improve with exercise. The aim of this study will be to investigate whether the implementation of an individualized exercise program will improve the functional status of patients with bipolar disorder (BD).
Methods: This longitudinal, interventional, randomized, controlled, simple-blind clinical trial will include 80 patients aged 18–65 years, all of them with BD diagnosis. Patients will be randomly assigned to a physical exercise intervention + Treatment-As-Usual (TAU) group and a non-intervention + TAU group. Patients will be assessed by an extensive battery of clinical tests, physical parameters (e.g., brain structure changes measured by optical coherence tomography, cardiorespiratory fitness) and biological parameters (inflammation, oxidative stress and neurotrophic factors) at baseline, after a 4-month intervention period, and 6-month follow-up.
Discussion: This is an innovative study aimed at gaining a deeper understanding of the physiopathology of BD and determining whether the prognosis and evolution of the disease can be improved through modifiable areas of the patient's lifestyle.
Clinical Trial Registration: NCT04400630. NCT clinicaltrials.gov. Date of registration in primary registry 22 May 2020. clinicaltrials.gov.