AUTHOR=Li Wenqiang , Su Xi , Chen Tengfei , Li Zhen , Yang Yongfeng , Zhang Luwen , Liu Qing , Shao Minglong , Zhang Yan , Ding Minli , Lu Yanli , Yu Hongyan , Fan Xiaoduo , Song Meng , Lv Luxian 

TITLE=Solute Carrier Family 1 (SLC1A1) Contributes to Susceptibility and Psychopathology Symptoms of Schizophrenia in the Han Chinese Population

JOURNAL=Frontiers in Psychiatry

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2020.559210

DOI=10.3389/fpsyt.2020.559210

ISSN=1664-0640

ABSTRACT=<sec><title>Objective</title><p>Schizophrenia (SZ) is a common and complex psychiatric disorder that has a significant genetic component. The glutamate hypothesis describes one possible pathogenesis of SZ. The solute carrier family 1 gene (<italic>SLC1A1</italic>) is one of several genes thought to play a critical role in regulating the glutamatergic system and is strongly implicated in the pathophysiology of SZ. In this study, we identify polymorphisms of the <italic>SLC1A1</italic> gene that may confer susceptibility to SZ in the Han Chinese population.</p></sec><sec><title>Methods</title><p>We genotyped 36 single-nucleotide polymorphisms (SNPs) using Illumina GoldenGate assays on a BeadStation 500G Genotyping System in 528 paranoid SZ patients and 528 healthy controls. Psychopathology was rated by the Positive and Negative Symptom Scale.</p></sec><sec><title>Results</title><p>Significant associations were found in genotype and allele frequencies for SNPs rs10815017 (<italic>p</italic> = 0.002, 0.030, respectively) and rs2026828 (<italic>p</italic> = 0.020, 0.005, respectively) between SZ and healthy controls. There were significant associations in genotype frequency at rs6476875 (<italic>p</italic> = 0.020) and rs7024664 (<italic>p</italic> = 0.021) and allele frequency at rs3780412 (<italic>p</italic> = 0.026) and rs10974573 (<italic>p</italic> = 0.047) between SZ and healthy controls. Meanwhile, significant differences were found in genotype frequency at rs10815017 (<italic>p</italic> = 0.015), rs2026828 (<italic>p</italic> = 0.011), and rs3780411 (<italic>p</italic> = 0.040) in males, and rs7021569 in females (<italic>p</italic> = 0.020) between cases and controls when subdivided by gender. Also, significant differences were found in allele frequency at rs2026828 (<italic>p</italic> = 0.003), and rs7021569 (<italic>p</italic> = 0.045) in males, and rs10974619 in females (<italic>p</italic> = 0.044). However, those associations disappeared after Bonferroni’s correction (<italic>p</italic>’s &gt; 0.05). Significant associations were found in the frequencies of four haplotypes (AA, CA, AGA, and GG) between SZ and healthy controls (<italic>χ</italic><sup>2</sup> = 3.974, 7.433, 4.699, 4.526, <italic>p</italic> = 0.046, 0.006, 0.030, 0.033, respectively). There were significant associations between rs7032326 genotypes and PANSS total, positive symptoms, negative symptoms, and general psychopathology in SZ (<italic>p</italic> = 0.002, 0.011, 0.028, 0.008, respectively).</p></sec><sec><title>Conclusion</title><p>The present study provides further evidence that <italic>SLC1A1</italic> may be not a susceptibility gene for SZ. However, the genetic variations of <italic>SLC1A1</italic> may affect psychopathology symptoms.</p></sec>