AUTHOR=Yang Jiarun , Ke Siyuan , Qiao Zhengxue , Yang Xiuxian , Qiu Xiaohui , Song Xuejia , Zhao Erying , Zhou Jiawei , Zhao Mingzhe , Yang Yanjie , Fang Deyu , Cao Depin 

TITLE=Interactions Between Glycogen Synthase Kinase-3β Gene Polymorphisms, Negative Life Events, and Susceptibility to Major Depressive Disorder in a Chinese Population

JOURNAL=Frontiers in Psychiatry

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2020.503477

DOI=10.3389/fpsyt.2020.503477

ISSN=1664-0640

ABSTRACT=<p><bold>Background:</bold> Recent studies suggest that glycogen synthase kinase (GSK)-3β is involved in the development of major depressive disorder (MDD). The aim of this study was to investigate the interaction between GSK-3β polymorphism (rs6438552, rs334558, and rs2199503) and negative life events in the pathogenesis of major depressive disorder (MDD).</p><p><bold>Methods:</bold> DNA genotyping was performed on peripheral blood leukocytes in 550 patients with MDD and 552 age- and gender-matched controls. The frequency and severity of negative life events were assessed by the Life Events Scale (LES). A chi-square method was employed to assess the gene-environment interaction (G × E).</p><p><bold>Results:</bold> Differences in rs6438552, rs334558, and rs2199503 genotype distributions were observed between MDD patients and controls. Significant G × E interactions between allelic variation of rs6438552, rs334558, and rs2199503 and negative life events were observed. Individuals with negative life events and carrying genotypes of rs6438552 A<sup>+</sup>, rs334558 A<sup>+</sup>, and rs2199503G<sup>+</sup> have increased the risk of depression.</p><p><bold>Conclusions:</bold> These results indicate that interactions between the GSK-3β rs6438552, rs334558, and rs2199503 polymorphisms and environment increases the risk of developing MDD.</p>