AUTHOR=Liao Jingping , Wang Ning , Ma Mengying , Lu Tianlan , Yan Hao , Yue Weihua 

TITLE=C677T Polymorphism in the MTHFR Gene Is Associated With Risperidone-Induced Weight Gain in Schizophrenia

JOURNAL=Frontiers in Psychiatry

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2020.00617

DOI=10.3389/fpsyt.2020.00617

ISSN=1664-0640

ABSTRACT=<sec><title>Objective</title><p>To explore the association of methylenetetrahydrofolate reductase (<italic>MTHFR</italic>) C677T polymorphism with risperidone-induced weight gain.</p></sec><sec><title>Methods</title><p>We analyzed the association between <italic>MTHFR</italic> C677T polymorphism and risperidone-induced weight gain in 356 schizophrenia patients. The patients were treated with risperidone for 8 weeks. The height and body weight of the patients were measured before and 8 weeks after risperidone treatment. Blood DNA was genotyped for <italic>MTHFR</italic> C677T polymorphisms.</p></sec><sec><title>Results</title><p>We found a significant association between <italic>MTHFR</italic> C677T polymorphism and body mass index (BMI) change after 8-week risperidone treatment. The BMI of carriers with different genotypes of <italic>MTHFR</italic> gene increased over 2–8 weeks. After 8 weeks of risperidone treatment, BMI added value (kg/m<sup>2</sup>) of CC or CT genotype carriers was significantly higher than that of TT genotype carriers [CC (4.47 ± 1.09), CT (4.54 ± 1.27), TT (2.31 ± 0.75), F = 5.634, P = 0.001]. Based on whether the rate of weight gain from baseline at 8 weeks of treatment exceeded 7%, it was divided into a weight gain group (n = 61) and a non-weight gain group (n = 295). The C allele frequency was significantly different between the two groups (48.4% vs 32.4%, <italic>χ<sup>2</sup></italic> = 11.342, P = 0.001).</p></sec><sec><title>Conclusion</title><p><italic>MTHFR</italic> C677T polymorphism was associated with risperidone-induced weight gain in Chinese Han population.</p></sec>